Cargando…

Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein

Intramembrane-cleaving proteases (I-CLiPs) play crucial roles in physiological and pathological processes, such as Alzheimer’s disease and cancer. However, the mechanisms of substrate recognition by I-CLiPs remain poorly understood. The aspartic I-CLiP presenilin is the catalytic subunit of the γ-se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clemente, Nicolina, Abdine, Alaa, Ubarretxena-Belandia, Iban, Wang, Chunyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098081/ https://www.ncbi.nlm.nih.gov/pubmed/30120254 http://dx.doi.org/10.1038/s41598-018-30015-6

Ejemplares similares

Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
por: Liu, Xinyue, et al.
Publicado: (2020)

Identification of an Archaeal Presenilin-Like Intramembrane Protease
por: Torres-Arancivia, Celia, et al.
Publicado: (2010)

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT
por: Merkle, Patrick S., et al.
Publicado: (2018)

Covalent fragment inhibits intramembrane proteolysis
por: Eden, Angela, et al.
Publicado: (2022)

Heme binding of transmembrane signaling proteins undergoing regulated intramembrane proteolysis
por: Kupke, Thomas, et al.
Publicado: (2020)

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase
por: Werner, Nadine T., et al.
Publicado: (2023)

Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis
por: Koistinen, Niina A., et al.
Publicado: (2017)

Transmembrane Helices Tilt, Bend, Slide, Torque, and Unwind between Functional States of Rhodopsin
por: Ren, Zhong, et al.
Publicado: (2016)

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates
por: Strisovsky, Kvido, et al.
Publicado: (2009)

Substrate interaction inhibits γ-secretase production of amyloid-β peptides
por: Zhao, Jing, et al.
Publicado: (2020)

Development of a Reporter System Monitoring Regulated Intramembrane Proteolysis of the Transmembrane bZIP Transcription Factor ATF6α
por: Kim, Jin-Ik, et al.
Publicado: (2019)

Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis
por: Ramírez-Guadiana, Fernando H., et al.
Publicado: (2018)

γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production
por: Takami, Mako, et al.
Publicado: (2012)

Formation of extramembrane β-strands controls dimerization of transmembrane helices in amyloid precursor protein C99
por: Pantelopulos, George A., et al.
Publicado: (2022)

Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis
por: Brogan, Anna P., et al.
Publicado: (2023)

Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics
por: Park, Hankum, et al.
Publicado: (2022)

Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase
por: Lemmin, Thomas, et al.
Publicado: (2014)

QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis
por: Ivankov, Dmitry N., et al.
Publicado: (2013)

Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis
por: Mentrup, Torben, et al.
Publicado: (2019)

Rhomboid-catalyzed intramembrane proteolysis requires hydrophobic matching with the surrounding lipid bilayer
por: Engberg, Oskar, et al.
Publicado: (2022)

Amyloid-like Fibrils from an α-Helical Transmembrane Protein
por: Stroobants, Karen, et al.
Publicado: (2017)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
por: Morishima-Kawashima, Maho
Publicado: (2014)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3
por: Degnin, Catherine R., et al.
Publicado: (2011)

The Coxsackievirus and Adenovirus Receptor (CAR) Undergoes Ectodomain Shedding and Regulated Intramembrane Proteolysis (RIP)
por: Houri, Nadia, et al.
Publicado: (2013)

Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release
por: Cho, Sangwoo, et al.
Publicado: (2019)

Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling
por: Bouza, Alexandra A., et al.
Publicado: (2021)

Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis
por: Mentrup, Torben, et al.
Publicado: (2022)

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite
por: O'Donnell, Rebecca A., et al.
Publicado: (2006)

Regulated Intramembrane Proteolysis and Degradation of Murine Epithelial Cell Adhesion Molecule mEpCAM
por: Hachmeister, Matthias, et al.
Publicado: (2013)

MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta
por: Lindert, Uschi, et al.
Publicado: (2016)

Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy
por: Wu, Bo, et al.
Publicado: (2017)

Regulated Intramembrane Proteolysis of ACE2: A Potential Mechanism Contributing to COVID-19 Pathogenesis?
por: Gonzalez, Sandra M., et al.
Publicado: (2021)

Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP
por: Imaizumi, Yuki, et al.
Publicado: (2022)

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
por: Feilen, Lukas P, et al.
Publicado: (2022)

Transmembrane α helices
por: Mall, Sanjay, et al.
Publicado: (2002)

Structural and Dynamic Study of the Transmembrane Domain of the Amyloid Precursor Protein
por: Nadezhdin, K.D., et al.
Publicado: (2011)

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis
por: Chen, Allen C., et al.
Publicado: (2015)

Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells
por: Lu, Yinzhong, et al.
Publicado: (2017)

Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function
por: Cho, Youngkyung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b3pil1akdref7gblhhd9n7nbt7