Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy

Indibulin, a synthetic inhibitor of tubulin assembly, has shown promising anticancer activity with a minimal neurotoxicity in preclinical animal studies and in Phase I clinical trials for cancer chemotherapy. Using time-lapse confocal microscopy, we show that indibulin dampens the dynamic instabilit...

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Detalles Bibliográficos
Autores principales: Kapoor, Sonia, Srivastava, Shalini, Panda, Dulal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098095/
https://www.ncbi.nlm.nih.gov/pubmed/30120268
http://dx.doi.org/10.1038/s41598-018-30376-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098095/
https://www.ncbi.nlm.nih.gov/pubmed/30120268
http://dx.doi.org/10.1038/s41598-018-30376-y

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