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Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress

Multiple cancer cells highly express cathepsin S, which has pro-tumoral effects. However, it was previously unknown whether knockdown or a pharmacological inhibitor (ZFL) of cathepsin S acts as an inducer of ER stress. Here, ZFL and knockdown of cathepsin S markedly induced ER stress through the up-...

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Detalles Bibliográficos
Autores principales:	Seo, Seung Un, Min, Kyoung-jin, Woo, Seon Min, Kwon, Taeg Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098103/ https://www.ncbi.nlm.nih.gov/pubmed/30120227 http://dx.doi.org/10.1038/s12276-018-0138-6

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