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Cognitive function following breast cancer treatment and associations with concurrent symptoms
Cognitive changes after breast cancer treatment are often attributed to chemotherapy, without considering other important factors such as other treatments (e.g., surgery, radiation, endocrine therapy (ET)). We compared neuropsychological functioning in the domains of learning, memory, attention, vis...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098124/ https://www.ncbi.nlm.nih.gov/pubmed/30131974 http://dx.doi.org/10.1038/s41523-018-0076-4 |
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author | Van Dyk, Kathleen Bower, Julienne E. Crespi, Catherine M. Petersen, Laura Ganz, Patricia A. |
author_facet | Van Dyk, Kathleen Bower, Julienne E. Crespi, Catherine M. Petersen, Laura Ganz, Patricia A. |
author_sort | Van Dyk, Kathleen |
collection | PubMed |
description | Cognitive changes after breast cancer treatment are often attributed to chemotherapy, without considering other important factors such as other treatments (e.g., surgery, radiation, endocrine therapy (ET)). We compared neuropsychological functioning in the domains of learning, memory, attention, visuospatial, executive function, and processing speed according to primary breast cancer treatment exposures in early survivorship, before the initiation of ET (n = 189). We were also interested in the association of neuropsychological functioning with select clinical, psychological, and behavioral factors. Compared to those who only underwent surgery (n = 28), all neuropsychological domain scores were comparable in a sample of breast cancer survivors with different treatment exposures, i.e., radiation therapy (n = 64), chemotherapy (n = 20), or both (n = 77), p’s < 0.05, adjusted for age, IQ, depression, and time since treatment completion. Physical fatigue, pain, and sleep correlated with several cognitive domains regardless of treatment exposure. There are minimal treatment-related neuropsychological differences on neuropsychological measures in early breast cancer survivorship, but the influence of other co-occurring symptoms warrants attention. |
format | Online Article Text |
id | pubmed-6098124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60981242018-08-21 Cognitive function following breast cancer treatment and associations with concurrent symptoms Van Dyk, Kathleen Bower, Julienne E. Crespi, Catherine M. Petersen, Laura Ganz, Patricia A. NPJ Breast Cancer Brief Communication Cognitive changes after breast cancer treatment are often attributed to chemotherapy, without considering other important factors such as other treatments (e.g., surgery, radiation, endocrine therapy (ET)). We compared neuropsychological functioning in the domains of learning, memory, attention, visuospatial, executive function, and processing speed according to primary breast cancer treatment exposures in early survivorship, before the initiation of ET (n = 189). We were also interested in the association of neuropsychological functioning with select clinical, psychological, and behavioral factors. Compared to those who only underwent surgery (n = 28), all neuropsychological domain scores were comparable in a sample of breast cancer survivors with different treatment exposures, i.e., radiation therapy (n = 64), chemotherapy (n = 20), or both (n = 77), p’s < 0.05, adjusted for age, IQ, depression, and time since treatment completion. Physical fatigue, pain, and sleep correlated with several cognitive domains regardless of treatment exposure. There are minimal treatment-related neuropsychological differences on neuropsychological measures in early breast cancer survivorship, but the influence of other co-occurring symptoms warrants attention. Nature Publishing Group UK 2018-08-17 /pmc/articles/PMC6098124/ /pubmed/30131974 http://dx.doi.org/10.1038/s41523-018-0076-4 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Brief Communication Van Dyk, Kathleen Bower, Julienne E. Crespi, Catherine M. Petersen, Laura Ganz, Patricia A. Cognitive function following breast cancer treatment and associations with concurrent symptoms |
title | Cognitive function following breast cancer treatment and associations with concurrent symptoms |
title_full | Cognitive function following breast cancer treatment and associations with concurrent symptoms |
title_fullStr | Cognitive function following breast cancer treatment and associations with concurrent symptoms |
title_full_unstemmed | Cognitive function following breast cancer treatment and associations with concurrent symptoms |
title_short | Cognitive function following breast cancer treatment and associations with concurrent symptoms |
title_sort | cognitive function following breast cancer treatment and associations with concurrent symptoms |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098124/ https://www.ncbi.nlm.nih.gov/pubmed/30131974 http://dx.doi.org/10.1038/s41523-018-0076-4 |
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