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mTOR-dependent phosphorylation controls TFEB nuclear export

During starvation the transcriptional activation of catabolic processes is induced by the nuclear translocation and consequent activation of transcription factor EB (TFEB), a master modulator of autophagy and lysosomal biogenesis. However, how TFEB is inactivated upon nutrient refeeding is currently...

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Detalles Bibliográficos
Autores principales:	Napolitano, Gennaro, Esposito, Alessandra, Choi, Heejun, Matarese, Maria, Benedetti, Valerio, Di Malta, Chiara, Monfregola, Jlenia, Medina, Diego Luis, Lippincott-Schwartz, Jennifer, Ballabio, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098152/ https://www.ncbi.nlm.nih.gov/pubmed/30120233 http://dx.doi.org/10.1038/s41467-018-05862-6

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