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Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics

BACKGROUND: The clinical significance of LINC00996 in colorectal cancer (CRC) has not been verified. In the current study, the authors aimed to explore the expression of LINC00996 and its clinical significance in CRC based on the data mining of Gene Expression Omnibus (GEO) and the Cancer Genome Atl...

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Autores principales: Ge, Hua, Yan, Yan, Wu, Di, Huang, Yongsheng, Tian, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098418/
https://www.ncbi.nlm.nih.gov/pubmed/30147336
http://dx.doi.org/10.2147/OTT.S173225
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author Ge, Hua
Yan, Yan
Wu, Di
Huang, Yongsheng
Tian, Fei
author_facet Ge, Hua
Yan, Yan
Wu, Di
Huang, Yongsheng
Tian, Fei
author_sort Ge, Hua
collection PubMed
description BACKGROUND: The clinical significance of LINC00996 in colorectal cancer (CRC) has not been verified. In the current study, the authors aimed to explore the expression of LINC00996 and its clinical significance in CRC based on the data mining of Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) datasets, as well as to elucidate the functions of its potential target genes. MATERIALS AND METHODS: GEO and TCGA microarray datasets were used to evaluate the LINC00996 expression and its clinical significance in CRC. LINC00996 related genes were identified by Multi Experiment Matrix, RNA-Binding Protein DataBase, and The Atlas of Noncoding RNAs in Cancer. Subsequently, they were sent to gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis. RESULTS: LINC00996 is significantly decreased in CRC tissues compared with non-tumor tissues. Low level of LINC00996 is associated with remote metastasis and poor overall survival. However, LINC00996 has a minimal effect on gender, lymphatic invasion, tumor size, lymph node metastasis, and pathological stage. One hundred and forty-two LINC00996 related genes were identified; the results of functional analysis indicated that LINC00996 might repress tumorigenesis and metastasis via modulating the JAK-STAT, NF-κB, HIF-1, TLR, and PI3K-AKT signaling pathways. CONCLUSION: Our study demonstrates that decreased LINC00996 expression may be involved in colorectal carcinogenesis and metastasis, and the depletion of LINC00996 is associated with a poor outcome in CRC patients. Moreover, the JAK-STAT, NF-κB, HIF-1, TLR, and PI3K-AKT pathways may be the key pathways regulated by LINC00996 in CRC.
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spelling pubmed-60984182018-08-24 Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics Ge, Hua Yan, Yan Wu, Di Huang, Yongsheng Tian, Fei Onco Targets Ther Original Research BACKGROUND: The clinical significance of LINC00996 in colorectal cancer (CRC) has not been verified. In the current study, the authors aimed to explore the expression of LINC00996 and its clinical significance in CRC based on the data mining of Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) datasets, as well as to elucidate the functions of its potential target genes. MATERIALS AND METHODS: GEO and TCGA microarray datasets were used to evaluate the LINC00996 expression and its clinical significance in CRC. LINC00996 related genes were identified by Multi Experiment Matrix, RNA-Binding Protein DataBase, and The Atlas of Noncoding RNAs in Cancer. Subsequently, they were sent to gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis. RESULTS: LINC00996 is significantly decreased in CRC tissues compared with non-tumor tissues. Low level of LINC00996 is associated with remote metastasis and poor overall survival. However, LINC00996 has a minimal effect on gender, lymphatic invasion, tumor size, lymph node metastasis, and pathological stage. One hundred and forty-two LINC00996 related genes were identified; the results of functional analysis indicated that LINC00996 might repress tumorigenesis and metastasis via modulating the JAK-STAT, NF-κB, HIF-1, TLR, and PI3K-AKT signaling pathways. CONCLUSION: Our study demonstrates that decreased LINC00996 expression may be involved in colorectal carcinogenesis and metastasis, and the depletion of LINC00996 is associated with a poor outcome in CRC patients. Moreover, the JAK-STAT, NF-κB, HIF-1, TLR, and PI3K-AKT pathways may be the key pathways regulated by LINC00996 in CRC. Dove Medical Press 2018-08-14 /pmc/articles/PMC6098418/ /pubmed/30147336 http://dx.doi.org/10.2147/OTT.S173225 Text en © 2018 Ge et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Ge, Hua
Yan, Yan
Wu, Di
Huang, Yongsheng
Tian, Fei
Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
title Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
title_full Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
title_fullStr Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
title_full_unstemmed Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
title_short Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
title_sort potential role of linc00996 in colorectal cancer: a study based on data mining and bioinformatics
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098418/
https://www.ncbi.nlm.nih.gov/pubmed/30147336
http://dx.doi.org/10.2147/OTT.S173225
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