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Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
BACKGROUND: The clinical significance of LINC00996 in colorectal cancer (CRC) has not been verified. In the current study, the authors aimed to explore the expression of LINC00996 and its clinical significance in CRC based on the data mining of Gene Expression Omnibus (GEO) and the Cancer Genome Atl...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098418/ https://www.ncbi.nlm.nih.gov/pubmed/30147336 http://dx.doi.org/10.2147/OTT.S173225 |
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author | Ge, Hua Yan, Yan Wu, Di Huang, Yongsheng Tian, Fei |
author_facet | Ge, Hua Yan, Yan Wu, Di Huang, Yongsheng Tian, Fei |
author_sort | Ge, Hua |
collection | PubMed |
description | BACKGROUND: The clinical significance of LINC00996 in colorectal cancer (CRC) has not been verified. In the current study, the authors aimed to explore the expression of LINC00996 and its clinical significance in CRC based on the data mining of Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) datasets, as well as to elucidate the functions of its potential target genes. MATERIALS AND METHODS: GEO and TCGA microarray datasets were used to evaluate the LINC00996 expression and its clinical significance in CRC. LINC00996 related genes were identified by Multi Experiment Matrix, RNA-Binding Protein DataBase, and The Atlas of Noncoding RNAs in Cancer. Subsequently, they were sent to gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis. RESULTS: LINC00996 is significantly decreased in CRC tissues compared with non-tumor tissues. Low level of LINC00996 is associated with remote metastasis and poor overall survival. However, LINC00996 has a minimal effect on gender, lymphatic invasion, tumor size, lymph node metastasis, and pathological stage. One hundred and forty-two LINC00996 related genes were identified; the results of functional analysis indicated that LINC00996 might repress tumorigenesis and metastasis via modulating the JAK-STAT, NF-κB, HIF-1, TLR, and PI3K-AKT signaling pathways. CONCLUSION: Our study demonstrates that decreased LINC00996 expression may be involved in colorectal carcinogenesis and metastasis, and the depletion of LINC00996 is associated with a poor outcome in CRC patients. Moreover, the JAK-STAT, NF-κB, HIF-1, TLR, and PI3K-AKT pathways may be the key pathways regulated by LINC00996 in CRC. |
format | Online Article Text |
id | pubmed-6098418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60984182018-08-24 Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics Ge, Hua Yan, Yan Wu, Di Huang, Yongsheng Tian, Fei Onco Targets Ther Original Research BACKGROUND: The clinical significance of LINC00996 in colorectal cancer (CRC) has not been verified. In the current study, the authors aimed to explore the expression of LINC00996 and its clinical significance in CRC based on the data mining of Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) datasets, as well as to elucidate the functions of its potential target genes. MATERIALS AND METHODS: GEO and TCGA microarray datasets were used to evaluate the LINC00996 expression and its clinical significance in CRC. LINC00996 related genes were identified by Multi Experiment Matrix, RNA-Binding Protein DataBase, and The Atlas of Noncoding RNAs in Cancer. Subsequently, they were sent to gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis. RESULTS: LINC00996 is significantly decreased in CRC tissues compared with non-tumor tissues. Low level of LINC00996 is associated with remote metastasis and poor overall survival. However, LINC00996 has a minimal effect on gender, lymphatic invasion, tumor size, lymph node metastasis, and pathological stage. One hundred and forty-two LINC00996 related genes were identified; the results of functional analysis indicated that LINC00996 might repress tumorigenesis and metastasis via modulating the JAK-STAT, NF-κB, HIF-1, TLR, and PI3K-AKT signaling pathways. CONCLUSION: Our study demonstrates that decreased LINC00996 expression may be involved in colorectal carcinogenesis and metastasis, and the depletion of LINC00996 is associated with a poor outcome in CRC patients. Moreover, the JAK-STAT, NF-κB, HIF-1, TLR, and PI3K-AKT pathways may be the key pathways regulated by LINC00996 in CRC. Dove Medical Press 2018-08-14 /pmc/articles/PMC6098418/ /pubmed/30147336 http://dx.doi.org/10.2147/OTT.S173225 Text en © 2018 Ge et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Ge, Hua Yan, Yan Wu, Di Huang, Yongsheng Tian, Fei Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics |
title | Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics |
title_full | Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics |
title_fullStr | Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics |
title_full_unstemmed | Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics |
title_short | Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics |
title_sort | potential role of linc00996 in colorectal cancer: a study based on data mining and bioinformatics |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098418/ https://www.ncbi.nlm.nih.gov/pubmed/30147336 http://dx.doi.org/10.2147/OTT.S173225 |
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