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Hexokinase 2 is dispensable for T cell-dependent immunity

BACKGROUND: T cells and cancer cells utilize glycolysis for proliferation. The hexokinase (1–4) family of enzymes catalyze the first step of glycolysis. Hexokinase 2 (HK2) is one of the most highly upregulated metabolic enzymes in both cancer and activated T cells. HK2 is required for the developmen...

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Detalles Bibliográficos
Autores principales:	Mehta, Manan M., Weinberg, Samuel E., Steinert, Elizabeth M., Chhiba, Krishan, Martinez, Carlos Alberto, Gao, Peng, Perlman, Harris R., Bryce, Paul, Hay, Nissim, Chandel, Navdeep S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098591/ https://www.ncbi.nlm.nih.gov/pubmed/30140438 http://dx.doi.org/10.1186/s40170-018-0184-5

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