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Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia

OBJECTIVES: Empirical selections of antimicrobial therapy based on clinical observations are common clinical practices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia. RESULTS: Among 210 patients studied, con...

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Autores principales: Belyhun, Yeshambel, Moges, Feleke, Endris, Mengistu, Asmare, Banchamlak, Amare, Bemnet, Bekele, Damtew, Tesfaye, Solomon, Alemayehu, Martha, Biadgelegne, Fantahun, Mulu, Andargachew, Assefa, Yared
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098601/
https://www.ncbi.nlm.nih.gov/pubmed/30119696
http://dx.doi.org/10.1186/s13104-018-3705-y
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author Belyhun, Yeshambel
Moges, Feleke
Endris, Mengistu
Asmare, Banchamlak
Amare, Bemnet
Bekele, Damtew
Tesfaye, Solomon
Alemayehu, Martha
Biadgelegne, Fantahun
Mulu, Andargachew
Assefa, Yared
author_facet Belyhun, Yeshambel
Moges, Feleke
Endris, Mengistu
Asmare, Banchamlak
Amare, Bemnet
Bekele, Damtew
Tesfaye, Solomon
Alemayehu, Martha
Biadgelegne, Fantahun
Mulu, Andargachew
Assefa, Yared
author_sort Belyhun, Yeshambel
collection PubMed
description OBJECTIVES: Empirical selections of antimicrobial therapy based on clinical observations are common clinical practices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia. RESULTS: Among 210 patients studied, conjunctivitis 32.9%(69), blepharitis 26.7%(56), dacryocystitis 14.8%(51), blepharoconjunctivitis 11.9%(25), and trauma 10.0%(21) were the most common external ocular infections. Pathogenic bacteria were isolated among 62.4%(131) cases. The distributions of bacteria detected in conjunctivitis, dacryocystitis, and blepharitis patients were 32.8%(43), 23.7%(31), and 16.0%(21), respectively. The most prevalent isolates were coagulase negative Staphylococci; 27.5%(36), S. aureus; 26.7%(35), Pseudomonas species; 10.7%(14), and E. coli; 7.6%(10). Tetracycline, amoxicillin, chloramphenicol, ampicillin, and nalidic acid showed resistance to bacterial isolates with a respective prevalence of 35.9%(47), 32.1%(42), 26.2%(34), 25.2%(33), and 23.7%(31). Multi-drug resistance patterns to the commonly prescribed antibiotics tested was 20.6%(27), 18.3%(24), 17.6%(23), 5.3%(7), and 4.6%(6) to two, three, four, five, and six antibiotics, respectively. Overall, the multi-drug resistance prevalence rate was 66.4%(87). This study confirmed diverse types of external ocular manifestations associated with bacterial infections with wide ranges of antibiotic resistant phenotypes. Thus, combining clinical information, bacteriological analysis, and antimicrobial susceptibility tests are useful for making an evidence-based selection of antibiotics therapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3705-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-60986012018-08-23 Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia Belyhun, Yeshambel Moges, Feleke Endris, Mengistu Asmare, Banchamlak Amare, Bemnet Bekele, Damtew Tesfaye, Solomon Alemayehu, Martha Biadgelegne, Fantahun Mulu, Andargachew Assefa, Yared BMC Res Notes Research Note OBJECTIVES: Empirical selections of antimicrobial therapy based on clinical observations are common clinical practices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia. RESULTS: Among 210 patients studied, conjunctivitis 32.9%(69), blepharitis 26.7%(56), dacryocystitis 14.8%(51), blepharoconjunctivitis 11.9%(25), and trauma 10.0%(21) were the most common external ocular infections. Pathogenic bacteria were isolated among 62.4%(131) cases. The distributions of bacteria detected in conjunctivitis, dacryocystitis, and blepharitis patients were 32.8%(43), 23.7%(31), and 16.0%(21), respectively. The most prevalent isolates were coagulase negative Staphylococci; 27.5%(36), S. aureus; 26.7%(35), Pseudomonas species; 10.7%(14), and E. coli; 7.6%(10). Tetracycline, amoxicillin, chloramphenicol, ampicillin, and nalidic acid showed resistance to bacterial isolates with a respective prevalence of 35.9%(47), 32.1%(42), 26.2%(34), 25.2%(33), and 23.7%(31). Multi-drug resistance patterns to the commonly prescribed antibiotics tested was 20.6%(27), 18.3%(24), 17.6%(23), 5.3%(7), and 4.6%(6) to two, three, four, five, and six antibiotics, respectively. Overall, the multi-drug resistance prevalence rate was 66.4%(87). This study confirmed diverse types of external ocular manifestations associated with bacterial infections with wide ranges of antibiotic resistant phenotypes. Thus, combining clinical information, bacteriological analysis, and antimicrobial susceptibility tests are useful for making an evidence-based selection of antibiotics therapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3705-y) contains supplementary material, which is available to authorized users. BioMed Central 2018-08-17 /pmc/articles/PMC6098601/ /pubmed/30119696 http://dx.doi.org/10.1186/s13104-018-3705-y Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Belyhun, Yeshambel
Moges, Feleke
Endris, Mengistu
Asmare, Banchamlak
Amare, Bemnet
Bekele, Damtew
Tesfaye, Solomon
Alemayehu, Martha
Biadgelegne, Fantahun
Mulu, Andargachew
Assefa, Yared
Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia
title Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia
title_full Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia
title_fullStr Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia
title_full_unstemmed Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia
title_short Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia
title_sort ocular bacterial infections and antibiotic resistance patterns in patients attending gondar teaching hospital, northwest ethiopia
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098601/
https://www.ncbi.nlm.nih.gov/pubmed/30119696
http://dx.doi.org/10.1186/s13104-018-3705-y
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