Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma

A composite lymphoma is the rare simultaneous occurrence of two or more distinct lymphomas within a single tissue or organ. Herein, we describe a case of a 51-year-old man presenting with a history of lower limb rash, fatigue, and bulky abdominopelvic lymphadenopathy. An excisional left iliac lymph...

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Autores principales: O'Neill, John Patrick, Quinn, Fiona, Dowling, Anita, Walker, Jan, Hayes, Triona, Bird, Brian, Flavin, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098847/
https://www.ncbi.nlm.nih.gov/pubmed/30155322
http://dx.doi.org/10.1155/2018/4312594
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author O'Neill, John Patrick
Quinn, Fiona
Dowling, Anita
Walker, Jan
Hayes, Triona
Bird, Brian
Flavin, Richard
author_facet O'Neill, John Patrick
Quinn, Fiona
Dowling, Anita
Walker, Jan
Hayes, Triona
Bird, Brian
Flavin, Richard
author_sort O'Neill, John Patrick
collection PubMed
description A composite lymphoma is the rare simultaneous occurrence of two or more distinct lymphomas within a single tissue or organ. Herein, we describe a case of a 51-year-old man presenting with a history of lower limb rash, fatigue, and bulky abdominopelvic lymphadenopathy. An excisional left iliac lymph node biopsy was notable for the composite presence of two distinct lymphoid neoplasms, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), and follicular lymphoma (FL). Multiplex PCR and FISH analyses failed to demonstrate a t(14;18)(q32;q21) translocation in either composite lymphoma component. A clonal light-chain kappa (V/JC intron-kde) gene rearrangement was detected in the FL component only.
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spelling pubmed-60988472018-08-28 Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma O'Neill, John Patrick Quinn, Fiona Dowling, Anita Walker, Jan Hayes, Triona Bird, Brian Flavin, Richard Case Rep Hematol Case Report A composite lymphoma is the rare simultaneous occurrence of two or more distinct lymphomas within a single tissue or organ. Herein, we describe a case of a 51-year-old man presenting with a history of lower limb rash, fatigue, and bulky abdominopelvic lymphadenopathy. An excisional left iliac lymph node biopsy was notable for the composite presence of two distinct lymphoid neoplasms, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), and follicular lymphoma (FL). Multiplex PCR and FISH analyses failed to demonstrate a t(14;18)(q32;q21) translocation in either composite lymphoma component. A clonal light-chain kappa (V/JC intron-kde) gene rearrangement was detected in the FL component only. Hindawi 2018-08-02 /pmc/articles/PMC6098847/ /pubmed/30155322 http://dx.doi.org/10.1155/2018/4312594 Text en Copyright © 2018 John Patrick O'Neill et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
O'Neill, John Patrick
Quinn, Fiona
Dowling, Anita
Walker, Jan
Hayes, Triona
Bird, Brian
Flavin, Richard
Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma
title Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma
title_full Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma
title_fullStr Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma
title_full_unstemmed Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma
title_short Composite t(14;18)-Negative Follicular Lymphoma and Nodular Lymphocyte-Predominant Hodgkin Lymphoma
title_sort composite t(14;18)-negative follicular lymphoma and nodular lymphocyte-predominant hodgkin lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098847/
https://www.ncbi.nlm.nih.gov/pubmed/30155322
http://dx.doi.org/10.1155/2018/4312594
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