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Therapeutic Potential of Stem Cells in Follicle Regeneration

Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with a...

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Autores principales: Owczarczyk-Saczonek, Agnieszka, Krajewska-Włodarczyk, Magdalena, Kruszewska, Anna, Banasiak, Łukasz, Placek, Waldemar, Maksymowicz, Wojciech, Wojtkiewicz, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098866/
https://www.ncbi.nlm.nih.gov/pubmed/30154860
http://dx.doi.org/10.1155/2018/1049641
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author Owczarczyk-Saczonek, Agnieszka
Krajewska-Włodarczyk, Magdalena
Kruszewska, Anna
Banasiak, Łukasz
Placek, Waldemar
Maksymowicz, Wojciech
Wojtkiewicz, Joanna
author_facet Owczarczyk-Saczonek, Agnieszka
Krajewska-Włodarczyk, Magdalena
Kruszewska, Anna
Banasiak, Łukasz
Placek, Waldemar
Maksymowicz, Wojciech
Wojtkiewicz, Joanna
author_sort Owczarczyk-Saczonek, Agnieszka
collection PubMed
description Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased incidence of the metabolic syndrome and an increased risk of the cardiac ischaemic disease. The ubiquity of alopecia provides an encouragement to seek new, more effective therapies aimed at hair follicle regeneration and neoregeneration. We know that stem cells can be used to regenerate hair in several therapeutic strategies: reversing the pathological mechanisms which contribute to hair loss, regeneration of complete hair follicles from their parts, and neogenesis of hair follicles from a stem cell culture with isolated cells or tissue engineering. Hair transplant has become a conventional treatment technique in androgenic alopecia (micrografts). Although an autologous transplant is regarded as the gold standard, its usability is limited, because of both a limited amount of material and a reduced viability of cells obtained in this way. The new therapeutic options are adipose-derived stem cells and stem cells from Wharton's jelly. They seem an ideal cell population for use in regenerative medicine because of the absence of immunogenic properties and their ease of obtainment, multipotential character, ease of differentiating into various cell lines, and considerable potential for angiogenesis. In this article, we presented advantages and limitations of using these types of cells in alopecia treatment.
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spelling pubmed-60988662018-08-28 Therapeutic Potential of Stem Cells in Follicle Regeneration Owczarczyk-Saczonek, Agnieszka Krajewska-Włodarczyk, Magdalena Kruszewska, Anna Banasiak, Łukasz Placek, Waldemar Maksymowicz, Wojciech Wojtkiewicz, Joanna Stem Cells Int Review Article Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased incidence of the metabolic syndrome and an increased risk of the cardiac ischaemic disease. The ubiquity of alopecia provides an encouragement to seek new, more effective therapies aimed at hair follicle regeneration and neoregeneration. We know that stem cells can be used to regenerate hair in several therapeutic strategies: reversing the pathological mechanisms which contribute to hair loss, regeneration of complete hair follicles from their parts, and neogenesis of hair follicles from a stem cell culture with isolated cells or tissue engineering. Hair transplant has become a conventional treatment technique in androgenic alopecia (micrografts). Although an autologous transplant is regarded as the gold standard, its usability is limited, because of both a limited amount of material and a reduced viability of cells obtained in this way. The new therapeutic options are adipose-derived stem cells and stem cells from Wharton's jelly. They seem an ideal cell population for use in regenerative medicine because of the absence of immunogenic properties and their ease of obtainment, multipotential character, ease of differentiating into various cell lines, and considerable potential for angiogenesis. In this article, we presented advantages and limitations of using these types of cells in alopecia treatment. Hindawi 2018-08-05 /pmc/articles/PMC6098866/ /pubmed/30154860 http://dx.doi.org/10.1155/2018/1049641 Text en Copyright © 2018 Agnieszka Owczarczyk-Saczonek et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Owczarczyk-Saczonek, Agnieszka
Krajewska-Włodarczyk, Magdalena
Kruszewska, Anna
Banasiak, Łukasz
Placek, Waldemar
Maksymowicz, Wojciech
Wojtkiewicz, Joanna
Therapeutic Potential of Stem Cells in Follicle Regeneration
title Therapeutic Potential of Stem Cells in Follicle Regeneration
title_full Therapeutic Potential of Stem Cells in Follicle Regeneration
title_fullStr Therapeutic Potential of Stem Cells in Follicle Regeneration
title_full_unstemmed Therapeutic Potential of Stem Cells in Follicle Regeneration
title_short Therapeutic Potential of Stem Cells in Follicle Regeneration
title_sort therapeutic potential of stem cells in follicle regeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098866/
https://www.ncbi.nlm.nih.gov/pubmed/30154860
http://dx.doi.org/10.1155/2018/1049641
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