The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway

Abelmoschus esculentus L. has favorable nutritional/medicinal features. We found the content of total flavonoids in flower extract to be the highest (788.56 mg/g) of all the different parts of A. esculentus; according to high-performance liquid chromatography, the quercetin-3-O-[β-D-glu-(1 → 6)]-β-D...

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Autores principales: Luo, Yang, Cui, Hong-Xin, Jia, An, Jia, Shan-Shan, Yuan, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098902/
https://www.ncbi.nlm.nih.gov/pubmed/30174782
http://dx.doi.org/10.1155/2018/8987173
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author Luo, Yang
Cui, Hong-Xin
Jia, An
Jia, Shan-Shan
Yuan, Ke
author_facet Luo, Yang
Cui, Hong-Xin
Jia, An
Jia, Shan-Shan
Yuan, Ke
author_sort Luo, Yang
collection PubMed
description Abelmoschus esculentus L. has favorable nutritional/medicinal features. We found the content of total flavonoids in flower extract to be the highest (788.56 mg/g) of all the different parts of A. esculentus; according to high-performance liquid chromatography, the quercetin-3-O-[β-D-glu-(1 → 6)]-β-D-glucopyranoside content was 122.13 mg/g. Protective effects of an extract of the total flavonoids of A. esculentus flowers (AFF) on transient cerebral ischemia-reperfusion injury (TCI-RI) were investigated. Compared with the model group, mice treated with AFF (300 mg/kg) for 7 days showed significantly reduced neurologic deficits, infarct area, and histologic changes in brain tissue, accompanied by increased contents of superoxide dismutase, whereas contents of nitric oxide and malondialdehyde decreased. AFF upregulated the expression of Nrf2, HO-1, and NQO1. These data suggest that AFF protects against TCI-RI by scavenging free radicals and activating the Nrf2-ARE pathway.
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spelling pubmed-60989022018-09-02 The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway Luo, Yang Cui, Hong-Xin Jia, An Jia, Shan-Shan Yuan, Ke Oxid Med Cell Longev Research Article Abelmoschus esculentus L. has favorable nutritional/medicinal features. We found the content of total flavonoids in flower extract to be the highest (788.56 mg/g) of all the different parts of A. esculentus; according to high-performance liquid chromatography, the quercetin-3-O-[β-D-glu-(1 → 6)]-β-D-glucopyranoside content was 122.13 mg/g. Protective effects of an extract of the total flavonoids of A. esculentus flowers (AFF) on transient cerebral ischemia-reperfusion injury (TCI-RI) were investigated. Compared with the model group, mice treated with AFF (300 mg/kg) for 7 days showed significantly reduced neurologic deficits, infarct area, and histologic changes in brain tissue, accompanied by increased contents of superoxide dismutase, whereas contents of nitric oxide and malondialdehyde decreased. AFF upregulated the expression of Nrf2, HO-1, and NQO1. These data suggest that AFF protects against TCI-RI by scavenging free radicals and activating the Nrf2-ARE pathway. Hindawi 2018-08-05 /pmc/articles/PMC6098902/ /pubmed/30174782 http://dx.doi.org/10.1155/2018/8987173 Text en Copyright © 2018 Yang Luo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Luo, Yang
Cui, Hong-Xin
Jia, An
Jia, Shan-Shan
Yuan, Ke
The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway
title The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway
title_full The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway
title_fullStr The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway
title_full_unstemmed The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway
title_short The Protective Effect of the Total Flavonoids of Abelmoschus esculentus L. Flowers on Transient Cerebral Ischemia-Reperfusion Injury Is due to Activation of the Nrf2-ARE Pathway
title_sort protective effect of the total flavonoids of abelmoschus esculentus l. flowers on transient cerebral ischemia-reperfusion injury is due to activation of the nrf2-are pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098902/
https://www.ncbi.nlm.nih.gov/pubmed/30174782
http://dx.doi.org/10.1155/2018/8987173
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