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Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents
INTRODUCTION: Nitric oxide (NOx) is an important biomolecule which interacts with other molecules including 25(OH)D to mediate various metabolic pathways. Interactions and associations of NOx with 25(OH)D have been well studied both in vitro and in vivo, yet associations in apparently healthy adoles...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098934/ https://www.ncbi.nlm.nih.gov/pubmed/30175114 http://dx.doi.org/10.1155/2018/1489132 |
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author | Al-Daghri, Nasser M. Bukhari, Ihtisham Yakout, Sobhy M. Sabico, Shaun Khattak, Malak N. K. Aziz, Ibrahim Alokail, Majed S. |
author_facet | Al-Daghri, Nasser M. Bukhari, Ihtisham Yakout, Sobhy M. Sabico, Shaun Khattak, Malak N. K. Aziz, Ibrahim Alokail, Majed S. |
author_sort | Al-Daghri, Nasser M. |
collection | PubMed |
description | INTRODUCTION: Nitric oxide (NOx) is an important biomolecule which interacts with other molecules including 25(OH)D to mediate various metabolic pathways. Interactions and associations of NOx with 25(OH)D have been well studied both in vitro and in vivo, yet associations in apparently healthy adolescents have never been studied. METHODS: A total of 740 (245 boys and 495 girls) apparently healthy Saudi adolescents aged 10-17 years were included in this cross-sectional study, to determine the associations of NOx with 25(OH)D and other biomarkers in Saudi adolescents. Serum NOx, 25(OH)D, and other biochemical and anthropometric parameters were measured following standard protocols and manufacturers' guidelines. RESULTS: NOx level was significantly higher in boys than girls (p<0.001). In all subjects, NOx showed a significant inverse correlation with 25(OH)D. After stratification according to sex however this significant association was observed only in boys and not in girls. NOx was also significantly associated with BMI, serum triglycerides, and systolic blood pressure in all subjects. CONCLUSION: The significantly inverse association of NOx and 25(OH)D among apparently healthy adolescents is influenced by sex and further strengthens the extraskeletal role of 25(OH)D in maintaining endothelial homeostasis in this age group, particularly in boys. Whether vitamin D correction can influence NOx production over time among adolescents remains to be proven. |
format | Online Article Text |
id | pubmed-6098934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60989342018-09-02 Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents Al-Daghri, Nasser M. Bukhari, Ihtisham Yakout, Sobhy M. Sabico, Shaun Khattak, Malak N. K. Aziz, Ibrahim Alokail, Majed S. Biomed Res Int Research Article INTRODUCTION: Nitric oxide (NOx) is an important biomolecule which interacts with other molecules including 25(OH)D to mediate various metabolic pathways. Interactions and associations of NOx with 25(OH)D have been well studied both in vitro and in vivo, yet associations in apparently healthy adolescents have never been studied. METHODS: A total of 740 (245 boys and 495 girls) apparently healthy Saudi adolescents aged 10-17 years were included in this cross-sectional study, to determine the associations of NOx with 25(OH)D and other biomarkers in Saudi adolescents. Serum NOx, 25(OH)D, and other biochemical and anthropometric parameters were measured following standard protocols and manufacturers' guidelines. RESULTS: NOx level was significantly higher in boys than girls (p<0.001). In all subjects, NOx showed a significant inverse correlation with 25(OH)D. After stratification according to sex however this significant association was observed only in boys and not in girls. NOx was also significantly associated with BMI, serum triglycerides, and systolic blood pressure in all subjects. CONCLUSION: The significantly inverse association of NOx and 25(OH)D among apparently healthy adolescents is influenced by sex and further strengthens the extraskeletal role of 25(OH)D in maintaining endothelial homeostasis in this age group, particularly in boys. Whether vitamin D correction can influence NOx production over time among adolescents remains to be proven. Hindawi 2018-08-05 /pmc/articles/PMC6098934/ /pubmed/30175114 http://dx.doi.org/10.1155/2018/1489132 Text en Copyright © 2018 Nasser M. Al-Daghri et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Al-Daghri, Nasser M. Bukhari, Ihtisham Yakout, Sobhy M. Sabico, Shaun Khattak, Malak N. K. Aziz, Ibrahim Alokail, Majed S. Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents |
title | Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents |
title_full | Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents |
title_fullStr | Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents |
title_full_unstemmed | Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents |
title_short | Associations of Serum Nitric Oxide with Vitamin D and Other Metabolic Factors in Apparently Healthy Adolescents |
title_sort | associations of serum nitric oxide with vitamin d and other metabolic factors in apparently healthy adolescents |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098934/ https://www.ncbi.nlm.nih.gov/pubmed/30175114 http://dx.doi.org/10.1155/2018/1489132 |
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