Eculizumab application during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: A case report with review of the literature

Eculizumab is highly effective in inhibiting complement activation and has successfully shown to prevent complications and to improve quality of life in patients with paroxysmal nocturnal hemoglobinuria (PNH). Its application during pregnancy showed favorable fetal and maternal outcome in the presen...

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Autores principales: Lauritsch‐Hernandez, Lisa Sophie, Kraehenmann, Franziska, Balabanov, Stefan, Kimmich, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099006/
https://www.ncbi.nlm.nih.gov/pubmed/30147909
http://dx.doi.org/10.1002/ccr3.1634
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author Lauritsch‐Hernandez, Lisa Sophie
Kraehenmann, Franziska
Balabanov, Stefan
Kimmich, Nina
author_facet Lauritsch‐Hernandez, Lisa Sophie
Kraehenmann, Franziska
Balabanov, Stefan
Kimmich, Nina
author_sort Lauritsch‐Hernandez, Lisa Sophie
collection PubMed
description Eculizumab is highly effective in inhibiting complement activation and has successfully shown to prevent complications and to improve quality of life in patients with paroxysmal nocturnal hemoglobinuria (PNH). Its application during pregnancy showed favorable fetal and maternal outcome in the presented case and has proven to be effective without raising safety concerns.
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spelling pubmed-60990062018-08-24 Eculizumab application during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: A case report with review of the literature Lauritsch‐Hernandez, Lisa Sophie Kraehenmann, Franziska Balabanov, Stefan Kimmich, Nina Clin Case Rep Case Reports Eculizumab is highly effective in inhibiting complement activation and has successfully shown to prevent complications and to improve quality of life in patients with paroxysmal nocturnal hemoglobinuria (PNH). Its application during pregnancy showed favorable fetal and maternal outcome in the presented case and has proven to be effective without raising safety concerns. John Wiley and Sons Inc. 2018-06-27 /pmc/articles/PMC6099006/ /pubmed/30147909 http://dx.doi.org/10.1002/ccr3.1634 Text en © 2018 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Lauritsch‐Hernandez, Lisa Sophie
Kraehenmann, Franziska
Balabanov, Stefan
Kimmich, Nina
Eculizumab application during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: A case report with review of the literature
title Eculizumab application during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: A case report with review of the literature
title_full Eculizumab application during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: A case report with review of the literature
title_fullStr Eculizumab application during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: A case report with review of the literature
title_full_unstemmed Eculizumab application during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: A case report with review of the literature
title_short Eculizumab application during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: A case report with review of the literature
title_sort eculizumab application during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: a case report with review of the literature
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099006/
https://www.ncbi.nlm.nih.gov/pubmed/30147909
http://dx.doi.org/10.1002/ccr3.1634
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