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Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy
Tumor-induced immune tolerance permits growth and spread of malignant cells. Cancer cells have strong influence on surrounding cells and shape the hypoxic tumor microenvironment (TME) facilitating cancer progression. A dynamic change in glucose metabolism occurring in cancer cells and its influence...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099109/ https://www.ncbi.nlm.nih.gov/pubmed/30151352 http://dx.doi.org/10.3389/fonc.2018.00284 |
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author | Wegiel, Barbara Vuerich, Marta Daneshmandi, Saeed Seth, Pankaj |
author_facet | Wegiel, Barbara Vuerich, Marta Daneshmandi, Saeed Seth, Pankaj |
author_sort | Wegiel, Barbara |
collection | PubMed |
description | Tumor-induced immune tolerance permits growth and spread of malignant cells. Cancer cells have strong influence on surrounding cells and shape the hypoxic tumor microenvironment (TME) facilitating cancer progression. A dynamic change in glucose metabolism occurring in cancer cells and its influence on the TME are still poorly understood. Indeed, cancer and/or immune cells undergo rapid adaptation in metabolic pathways during cancer progression. Metabolic reprograming affects macrophages, T cells, and myeloid derived suppressor cells (MDSCs) among other immune cells. Their role in the TME depends on a nature and concentration of factors, such as cytokines, reactive oxygen species (ROS), growth factors, and most importantly, diffusible metabolites (i.e., lactate). Further, the amounts of available nutrients and oxygen as well as activity of microbiota may influence metabolic pathways in the TME. The roles of metabolites in regulating of the interaction between immune and cancer cell are highlighted in this review. Targeting metabolic reprogramming or signaling pathways controlling cell metabolism in the TME might be a potential strategy for anti-cancer therapy alone or in combination with current immunotherapies. |
format | Online Article Text |
id | pubmed-6099109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60991092018-08-27 Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy Wegiel, Barbara Vuerich, Marta Daneshmandi, Saeed Seth, Pankaj Front Oncol Oncology Tumor-induced immune tolerance permits growth and spread of malignant cells. Cancer cells have strong influence on surrounding cells and shape the hypoxic tumor microenvironment (TME) facilitating cancer progression. A dynamic change in glucose metabolism occurring in cancer cells and its influence on the TME are still poorly understood. Indeed, cancer and/or immune cells undergo rapid adaptation in metabolic pathways during cancer progression. Metabolic reprograming affects macrophages, T cells, and myeloid derived suppressor cells (MDSCs) among other immune cells. Their role in the TME depends on a nature and concentration of factors, such as cytokines, reactive oxygen species (ROS), growth factors, and most importantly, diffusible metabolites (i.e., lactate). Further, the amounts of available nutrients and oxygen as well as activity of microbiota may influence metabolic pathways in the TME. The roles of metabolites in regulating of the interaction between immune and cancer cell are highlighted in this review. Targeting metabolic reprogramming or signaling pathways controlling cell metabolism in the TME might be a potential strategy for anti-cancer therapy alone or in combination with current immunotherapies. Frontiers Media S.A. 2018-08-13 /pmc/articles/PMC6099109/ /pubmed/30151352 http://dx.doi.org/10.3389/fonc.2018.00284 Text en Copyright © 2018 Wegiel, Vuerich, Daneshmandi and Seth. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wegiel, Barbara Vuerich, Marta Daneshmandi, Saeed Seth, Pankaj Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy |
title | Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy |
title_full | Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy |
title_fullStr | Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy |
title_full_unstemmed | Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy |
title_short | Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy |
title_sort | metabolic switch in the tumor microenvironment determines immune responses to anti-cancer therapy |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099109/ https://www.ncbi.nlm.nih.gov/pubmed/30151352 http://dx.doi.org/10.3389/fonc.2018.00284 |
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