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Synergistic Effect of Simvastatin and Romidepsin on Gamma-globin Gene Induction

OBJECTIVE: Hemoglobinopathies such as beta-thalassemia and sickle cell disease (SCD) are inherited disorders that are caused by mutations in beta-globin chain. Gamma-globin gene reactivation can ameliorate clinical manifestations of beta- thalassemia and SCD. Drugs that induce fetal hemoglobin (HbF)...

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Detalles Bibliográficos
Autores principales:	Habibi, Hussain, Atashi, Amir, Abroun, Saeid, Noruzinia, Mehrdad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royan Institute 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099151/ https://www.ncbi.nlm.nih.gov/pubmed/30124006 http://dx.doi.org/10.22074/cellj.2019.5589

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