Ribociclib Bioavailability Is Not Affected by Gastric pH Changes or Food Intake: In Silico and Clinical Evaluations

Ribociclib (KISQALI), a cyclin‐dependent kinase 4/6 inhibitor approved for the first‐line treatment of HR+/HER2– advanced breast cancer with an aromatase inhibitor, is administered with no restrictions on concomitant gastric pH‐elevating agents or food intake. The influence of proton pump inhibitors...

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Detalles Bibliográficos
Autores principales: Samant, Tanay S., Dhuria, Shyeilla, Lu, Yasong, Laisney, Marc, Yang, Shu, Grandeury, Arnaud, Mueller‐Zsigmondy, Martin, Umehara, Kenichi, Huth, Felix, Miller, Michelle, Germa, Caroline, Elmeliegy, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099197/
https://www.ncbi.nlm.nih.gov/pubmed/29134635
http://dx.doi.org/10.1002/cpt.940

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