Psychopharmacological effects and safety of styryl‐2‐pyrones and dihydrostyryl‐2‐pyrones‐rich fraction from Polygala sabulosa: absence of withdrawal syndrome and tolerance to anxiolytic‐like and anticonvulsant effects

OBJECTIVES: To investigate whether mice develop tolerance to the anxiolytic‐like and anticonvulsant effects of subchronic treatment with EA (the styryl‐2‐pyrones and dihydrostyryl‐2‐pyrones‐rich fraction of Polygala sabulosa), as well as any withdrawal symptoms after abrupt discontinuation; to compa...

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Detalles Bibliográficos
Autores principales: Duarte, Filipe Silveira, Duzzioni, Marcelo, Prim, Rafael Luiz, Cardozo, Alcíbia Maia, dos Santos, Claudia Regina, da Silva, Maria Goretti, Shiozawa, Maria Beatriz Cacese, Mendes, Beatriz Garcia, Tizziani, Tiago, Brighente, Inês Maria Costa, Pizzolatti, Moacir Geraldo, de Lima, Thereza Christina Monteiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Drugs from Natural Sources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099234/
https://www.ncbi.nlm.nih.gov/pubmed/29956326
http://dx.doi.org/10.1111/jphp.12960

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