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Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer
Ectopic (or tertiary) lymphoid structures (ELS) are organized aggregates of lymphocytes resembling secondary lymphoid organs and developing in chronically inflamed nonlymphoid tissues during persistent infections, graft rejection, autoimmune conditions, and cancer. In this review, we will first depi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099300/ https://www.ncbi.nlm.nih.gov/pubmed/29947426 http://dx.doi.org/10.1002/JLB.3MR0218-062R |
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author | Nerviani, Alessandra Pitzalis, Costantino |
author_facet | Nerviani, Alessandra Pitzalis, Costantino |
author_sort | Nerviani, Alessandra |
collection | PubMed |
description | Ectopic (or tertiary) lymphoid structures (ELS) are organized aggregates of lymphocytes resembling secondary lymphoid organs and developing in chronically inflamed nonlymphoid tissues during persistent infections, graft rejection, autoimmune conditions, and cancer. In this review, we will first depict the mechanisms regulating ELS generation, focusing on the role played by lymphoid chemokines. We will then characterize ELS forming in target organs during autoimmune conditions, here exemplified by rheumatoid arthritis, and cancer, highlighting the relevance of the tissue‐specific factors. Finally, we will discuss the clinical significance of ELS and the therapeutic potential of their inhibition and/or enhancement depending on the disease considered. |
format | Online Article Text |
id | pubmed-6099300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60993002018-08-23 Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer Nerviani, Alessandra Pitzalis, Costantino J Leukoc Biol Special Focus Issue Ectopic (or tertiary) lymphoid structures (ELS) are organized aggregates of lymphocytes resembling secondary lymphoid organs and developing in chronically inflamed nonlymphoid tissues during persistent infections, graft rejection, autoimmune conditions, and cancer. In this review, we will first depict the mechanisms regulating ELS generation, focusing on the role played by lymphoid chemokines. We will then characterize ELS forming in target organs during autoimmune conditions, here exemplified by rheumatoid arthritis, and cancer, highlighting the relevance of the tissue‐specific factors. Finally, we will discuss the clinical significance of ELS and the therapeutic potential of their inhibition and/or enhancement depending on the disease considered. John Wiley and Sons Inc. 2018-06-27 2018-08 /pmc/articles/PMC6099300/ /pubmed/29947426 http://dx.doi.org/10.1002/JLB.3MR0218-062R Text en ©2018 The Authors. Society for Leukocyte Biology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Special Focus Issue Nerviani, Alessandra Pitzalis, Costantino Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer |
title | Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer |
title_full | Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer |
title_fullStr | Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer |
title_full_unstemmed | Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer |
title_short | Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer |
title_sort | role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer |
topic | Special Focus Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099300/ https://www.ncbi.nlm.nih.gov/pubmed/29947426 http://dx.doi.org/10.1002/JLB.3MR0218-062R |
work_keys_str_mv | AT nervianialessandra roleofchemokinesinectopiclymphoidstructuresformationinautoimmunityandcancer AT pitzaliscostantino roleofchemokinesinectopiclymphoidstructuresformationinautoimmunityandcancer |