Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation‐negative early‐onset and high‐risk breast cancer patients

To evaluate the role of constitutive epigenetic changes in normal body cells of BRCA1/BRCA2‐mutation negative patients, we have developed a deep bisulfite sequencing assay targeting the promoter regions of 8 tumor suppressor (TS) genes (BRCA1, BRCA2, RAD51C, ATM, PTEN, TP53, MLH1, RB1) and the estro...

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Detalles Bibliográficos
Autores principales: Böck, Julia, Appenzeller, Silke, Haertle, Larissa, Schneider, Tamara, Gehrig, Andrea, Schröder, Jörg, Rost, Simone, Wolf, Beat, Bartram, Claus R., Sutter, Christian, Haaf, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cancer Genetics and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099327/
https://www.ncbi.nlm.nih.gov/pubmed/29659014
http://dx.doi.org/10.1002/ijc.31526

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