The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine

The Babraham pig is a highly inbred breed first developed in the United Kingdom approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the major histocompatibility complex (MHC) region, but confirmation of homozygosity at the specific MH...

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Autores principales: Schwartz, J. C., Hemmink, J. D., Graham, S. P., Tchilian, E., Charleston, B., Hammer, S. E., Ho, C.‐S., Hammond, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099331/
https://www.ncbi.nlm.nih.gov/pubmed/29687612
http://dx.doi.org/10.1111/tan.13281
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author Schwartz, J. C.
Hemmink, J. D.
Graham, S. P.
Tchilian, E.
Charleston, B.
Hammer, S. E.
Ho, C.‐S.
Hammond, J. A.
author_facet Schwartz, J. C.
Hemmink, J. D.
Graham, S. P.
Tchilian, E.
Charleston, B.
Hammer, S. E.
Ho, C.‐S.
Hammond, J. A.
author_sort Schwartz, J. C.
collection PubMed
description The Babraham pig is a highly inbred breed first developed in the United Kingdom approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the major histocompatibility complex (MHC) region, but confirmation of homozygosity at the specific MHC loci was lacking. Using both direct sequencing and PCR‐based sequence‐specific typing, we confirm that Babraham pigs are essentially homozygous at their MHC loci and formalise their MHC haplotype as Hp‐55.6. This enhances the utility of the Babraham pig as a useful biomedical model for studies in which controlling for genetic variation is important.
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spelling pubmed-60993312018-08-23 The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine Schwartz, J. C. Hemmink, J. D. Graham, S. P. Tchilian, E. Charleston, B. Hammer, S. E. Ho, C.‐S. Hammond, J. A. HLA Brief Communication The Babraham pig is a highly inbred breed first developed in the United Kingdom approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the major histocompatibility complex (MHC) region, but confirmation of homozygosity at the specific MHC loci was lacking. Using both direct sequencing and PCR‐based sequence‐specific typing, we confirm that Babraham pigs are essentially homozygous at their MHC loci and formalise their MHC haplotype as Hp‐55.6. This enhances the utility of the Babraham pig as a useful biomedical model for studies in which controlling for genetic variation is important. Blackwell Publishing Ltd 2018-06-01 2018-07 /pmc/articles/PMC6099331/ /pubmed/29687612 http://dx.doi.org/10.1111/tan.13281 Text en © 2018 The Authors. HLA published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Schwartz, J. C.
Hemmink, J. D.
Graham, S. P.
Tchilian, E.
Charleston, B.
Hammer, S. E.
Ho, C.‐S.
Hammond, J. A.
The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
title The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
title_full The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
title_fullStr The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
title_full_unstemmed The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
title_short The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine
title_sort major histocompatibility complex homozygous inbred babraham pig as a resource for veterinary and translational medicine
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099331/
https://www.ncbi.nlm.nih.gov/pubmed/29687612
http://dx.doi.org/10.1111/tan.13281
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