Cargando…

Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids

OBJECTIVE: To develop an objective, readily measurable pharmacodynamic biomarker of glucocorticoid (GC) activity. METHODS: Genes modulated by prednisolone were identified from in vitro studies using peripheral blood mononuclear cells from normal healthy volunteers. Using the criteria of a >2‐fold...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Yanhua, Carman, Julie A., Holloway, Deborah, Kansal, Selena, Fan, Li, Goldstine, Christine, Lee, Deborah, Somerville, John E., Latek, Robert, Townsend, Robert, Johnsen, Alyssa, Connolly, Sean, Bandyopadhyay, Somnath, Shadick, Nancy, Weinblatt, Michael E., Furie, Richard, Nadler, Steven G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Autoimmune Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099349/ https://www.ncbi.nlm.nih.gov/pubmed/29534336 http://dx.doi.org/10.1002/art.40476

Ejemplares similares

Systemic Autoimmune Disease Among Adults Exposed to the September 11, 2001 Terrorist Attack
por: Miller‐Archie, Sara A., et al.
Publicado: (2020)

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice
por: Sood, Shatakshi, et al.
Publicado: (2016)

Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
por: Burska, Agata, et al.
Publicado: (2023)

Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
por: Rodríguez-Carrio, Javier, et al.
Publicado: (2023)

Efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases: a systematic literature review for the 2019 update of EULAR recommendations
por: Rondaan, Christien, et al.
Publicado: (2019)

Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis
por: Giles, Joanna L., et al.
Publicado: (2015)

Cancer immunotherapy-induced rheumatic diseases emerge as new clinical entities
por: Cappelli, Laura C, et al.
Publicado: (2016)

Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding–Defective Mutant of ABIN1
por: Nanda, Sambit K., et al.
Publicado: (2016)

Tissue-Resident Exhausted Effector Memory CD8(+) T Cells Accumulate in the Retina during Chronic Experimental Autoimmune Uveoretinitis
por: Boldison, Joanne, et al.
Publicado: (2014)

Characteristics and treatment of new-onset arthritis after checkpoint inhibitor therapy
por: Leipe, Jan, et al.
Publicado: (2018)

Distinct features distinguishing IgG4-related disease from multicentric Castleman’s disease
por: Sasaki, Takanori, et al.
Publicado: (2017)

The Lupus‐Associated Fcγ Receptor IIb–I232T Polymorphism Results in Impairment in the Negative Selection of Low‐Affinity Germinal Center B Cells Via c‐Abl in Mice
por: Jhou, Jyun‐Pei, et al.
Publicado: (2018)

Antiphospholipid syndrome: state of the art on clinical practice guidelines
por: Limper, Marteen, et al.
Publicado: (2018)

Automated evaluation of ANA under real-life conditions
por: Loock, Clemens Dario, et al.
Publicado: (2017)

Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity
por: Roberts, Natalie A., et al.
Publicado: (2017)

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology
por: Brucklacher-Waldert, Verena, et al.
Publicado: (2016)

Rheumatic immune-related adverse events of checkpoint therapy for cancer: case series of a new nosological entity
por: Calabrese, C, et al.
Publicado: (2017)

Recognising the spectrum of scleromyositis: HEp-2 ANA patterns allow identification of a novel clinical subset with anti-SMN autoantibodies
por: Landon-Cardinal, Océane, et al.
Publicado: (2020)

Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a systematic literature research
por: Kerschbaumer, Andreas, et al.
Publicado: (2020)

Point of view on the vaccination against COVID-19 in patients with autoimmune inflammatory rheumatic diseases
por: Furer, Victoria, et al.
Publicado: (2021)

Inflammaging as a link between autoimmunity and cardiovascular disease: the case of rheumatoid arthritis
por: Santos-Moreno, Pedro, et al.
Publicado: (2021)

Current status of use of high throughput nucleotide sequencing in rheumatology
por: Boegel, Sebastian, et al.
Publicado: (2021)

Association between T follicular helper cells and T peripheral helper cells with B-cell biomarkers and disease activity in primary Sjögren syndrome
por: Dupré, Anastasia, et al.
Publicado: (2021)

Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease
por: Tomofuji, Yoshihiko, et al.
Publicado: (2022)

Rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren’s syndrome shared megakaryocyte expansion in peripheral blood
por: Wang, Yukai, et al.
Publicado: (2022)

Association between long-term exposure to air pollution and immune-mediated diseases: a population-based cohort study
por: Adami, Giovanni, et al.
Publicado: (2022)

Direct oral anticoagulants versus vitamin K antagonists in patients with antiphospholipid syndrome: systematic review and meta-analysis
por: Koval, Nazariy, et al.
Publicado: (2021)

A systematic literature review informing the consensus statement on efficacy and safety of pharmacological treatment with interleukin-6 pathway inhibition with biological DMARDs in immune-mediated inflammatory diseases
por: Kastrati, Kastriot, et al.
Publicado: (2022)

Immune-mediated inflammatory diseases after anti-SARS-CoV-2 vaccines: new diagnoses and disease flares
por: Carubbi, Francesco, et al.
Publicado: (2022)

Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component
por: Shirai, Yuya, et al.
Publicado: (2022)

Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis
por: Yan, Songxin, et al.
Publicado: (2022)

Machine Learning for the Identification of a Common Signature for Anti–SSA/Ro 60 Antibody Expression Across Autoimmune Diseases
por: Foulquier, Nathan, et al.
Publicado: (2022)

Tolerance and efficacy of targeted therapies prescribed for off-label indications in refractory systemic autoimmune diseases: data of the first 100 patients enrolled in the TATA registry (TArgeted Therapy in Autoimmune Diseases)
por: Gottenberg, Jacques-Eric, et al.
Publicado: (2022)

Interferon signature in systemic autoimmune diseases: what does it mean?
por: Nocturne, Gaetane, et al.
Publicado: (2022)

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity
por: Hodgson, Rose, et al.
Publicado: (2023)

Identifying high-risk profile in primary antiphospholipid syndrome through cluster analysis: French multicentric cohort study
por: Guedon, Alexis F, et al.
Publicado: (2023)

Thrombotic and immunological phenomena following COVID-19 vaccination: experience from a case series
por: Dandeniya, Chathurika Lakmini, et al.
Publicado: (2023)

Adipokine profile in long-term juvenile dermatomyositis, and associations with adipose tissue distribution and cardiac function: a cross-sectional study
por: Marstein, Henriette Schermacher, et al.
Publicado: (2023)

Triple positive profile in antiphospholipid syndrome: prognosis, relapse and management from a retrospective multicentre study
por: Laurent, Charlotte, et al.
Publicado: (2023)

Associations between nailfold capillary aberrations and autoantibodies in children and adults with Raynaud’s phenomenon
por: Mueller, Markus, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4p5sm1b3kdt38gfcqhgb77tb4e