A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity

Phytochemical investigations of the leaves and stems of Pseuduvaria fragrans led to the isolation of a new benzophenone C-glucoside named pseuduvarioside (1), together with six known compounds including (−)-guaiol (2), (+)-isocorydine (3), cyathocaline (4), isoursoline (5), N-trans-coumaroyltyramine...

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Autores principales: Panidthananon, Wongvarit, Chaowasku, Tanawat, Sritularak, Boonchoo, Likhitwitayawuid, Kittisak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099400/
https://www.ncbi.nlm.nih.gov/pubmed/30004411
http://dx.doi.org/10.3390/molecules23071600
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author Panidthananon, Wongvarit
Chaowasku, Tanawat
Sritularak, Boonchoo
Likhitwitayawuid, Kittisak
author_facet Panidthananon, Wongvarit
Chaowasku, Tanawat
Sritularak, Boonchoo
Likhitwitayawuid, Kittisak
author_sort Panidthananon, Wongvarit
collection PubMed
description Phytochemical investigations of the leaves and stems of Pseuduvaria fragrans led to the isolation of a new benzophenone C-glucoside named pseuduvarioside (1), together with six known compounds including (−)-guaiol (2), (+)-isocorydine (3), cyathocaline (4), isoursoline (5), N-trans-coumaroyltyramine (6), and N-trans-feruloyltyramine (7). Their structures were characterized by NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for inhibitory activity against the enzyme α-glucosidase. N-trans-coumaroyltyramine and N-trans-feruloyltyramine showed higher activity than the drug acarbose. Kinetic studies revealed that both tyramine-derived amides were uncompetitive inhibitors of the enzyme.
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spelling pubmed-60994002018-11-13 A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity Panidthananon, Wongvarit Chaowasku, Tanawat Sritularak, Boonchoo Likhitwitayawuid, Kittisak Molecules Article Phytochemical investigations of the leaves and stems of Pseuduvaria fragrans led to the isolation of a new benzophenone C-glucoside named pseuduvarioside (1), together with six known compounds including (−)-guaiol (2), (+)-isocorydine (3), cyathocaline (4), isoursoline (5), N-trans-coumaroyltyramine (6), and N-trans-feruloyltyramine (7). Their structures were characterized by NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for inhibitory activity against the enzyme α-glucosidase. N-trans-coumaroyltyramine and N-trans-feruloyltyramine showed higher activity than the drug acarbose. Kinetic studies revealed that both tyramine-derived amides were uncompetitive inhibitors of the enzyme. MDPI 2018-07-02 /pmc/articles/PMC6099400/ /pubmed/30004411 http://dx.doi.org/10.3390/molecules23071600 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Panidthananon, Wongvarit
Chaowasku, Tanawat
Sritularak, Boonchoo
Likhitwitayawuid, Kittisak
A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity
title A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity
title_full A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity
title_fullStr A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity
title_full_unstemmed A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity
title_short A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity
title_sort new benzophenone c-glucoside and other constituents of pseuduvaria fragrans and their α-glucosidase inhibitory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099400/
https://www.ncbi.nlm.nih.gov/pubmed/30004411
http://dx.doi.org/10.3390/molecules23071600
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