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Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults

NEW FINDINGS: What is the central question of this study? Nitric oxide causes dilatation in peripheral vessels; however, whether nitric oxide affects basal cerebral artery dilatation has not been explored. What is the main finding and its importance? This study demonstrated that vasodilatation occur...

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Autores principales: Schulz, Jenna M., Al‐Khazraji, Baraa K., Shoemaker, J. Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099468/
https://www.ncbi.nlm.nih.gov/pubmed/29766604
http://dx.doi.org/10.1113/EP087022
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author Schulz, Jenna M.
Al‐Khazraji, Baraa K.
Shoemaker, J. Kevin
author_facet Schulz, Jenna M.
Al‐Khazraji, Baraa K.
Shoemaker, J. Kevin
author_sort Schulz, Jenna M.
collection PubMed
description NEW FINDINGS: What is the central question of this study? Nitric oxide causes dilatation in peripheral vessels; however, whether nitric oxide affects basal cerebral artery dilatation has not been explored. What is the main finding and its importance? This study demonstrated that vasodilatation occurs in the right middle cerebral artery in response to exogenous nitric oxide. However, blood velocity decreased and, therefore, overall cerebral blood flow remained unchanged. This study provides new insight into the role of nitric oxide in cerebral blood flow control. ABSTRACT: Recent evidence indicates that basal cerebral conduit vessels dilate with hypercapnia, with a nitric oxide (NO) mechanism explaining one way in which parenchymal cerebral arterioles dilate. However, whether NO affects basal cerebral artery dilatation remains unknown. This study quantified the effect of an exogenous NO donor [sodium nitroglycerin (NTG); 0.4 mg sublingual spray] on the right middle cerebral artery (rMCA) cross‐sectional area (CSA), blood velocity and overall blood flow. Measures of vessel CSA (7 T magnetic resonance imaging) and MCA blood velocity (transcranial Doppler ultrasound) were made at baseline (BL) and after exogenous NTG or placebo (PLO) administration in young, healthy individuals (n = 10, two males, age range 20–23 years). The CSA increased in the rMCA [BL, 5.2 ± 1.2 mm(2); PLO, 5.4 ± 1.5 mm(2); NTG, 6.6 ± 1.5 mm(2), P < 0.05; mean ± SD]. Concurrently, rMCA blood velocity decreased from BL during NTG compared with PLO (BL, 67 ± 10 cm s(−1); PLO, 62 ± 10 cm s(−1); NTG, 59 ± 9.3 cm s(−1), P < 0.05; mean ± SD]. However, total MCA blood flow did not change with NTG or PLO [BL, 221 ± 37.4 ml min(−1); PLO, 218 ± 35.0 ml min(−1); NTG, 213 ± 46.4 ml min(−1)). Therefore, exogenous NO mediates a dilatory response in the rMCA, but not in its downstream vascular bed.
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spelling pubmed-60994682018-08-24 Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults Schulz, Jenna M. Al‐Khazraji, Baraa K. Shoemaker, J. Kevin Exp Physiol Research Papers NEW FINDINGS: What is the central question of this study? Nitric oxide causes dilatation in peripheral vessels; however, whether nitric oxide affects basal cerebral artery dilatation has not been explored. What is the main finding and its importance? This study demonstrated that vasodilatation occurs in the right middle cerebral artery in response to exogenous nitric oxide. However, blood velocity decreased and, therefore, overall cerebral blood flow remained unchanged. This study provides new insight into the role of nitric oxide in cerebral blood flow control. ABSTRACT: Recent evidence indicates that basal cerebral conduit vessels dilate with hypercapnia, with a nitric oxide (NO) mechanism explaining one way in which parenchymal cerebral arterioles dilate. However, whether NO affects basal cerebral artery dilatation remains unknown. This study quantified the effect of an exogenous NO donor [sodium nitroglycerin (NTG); 0.4 mg sublingual spray] on the right middle cerebral artery (rMCA) cross‐sectional area (CSA), blood velocity and overall blood flow. Measures of vessel CSA (7 T magnetic resonance imaging) and MCA blood velocity (transcranial Doppler ultrasound) were made at baseline (BL) and after exogenous NTG or placebo (PLO) administration in young, healthy individuals (n = 10, two males, age range 20–23 years). The CSA increased in the rMCA [BL, 5.2 ± 1.2 mm(2); PLO, 5.4 ± 1.5 mm(2); NTG, 6.6 ± 1.5 mm(2), P < 0.05; mean ± SD]. Concurrently, rMCA blood velocity decreased from BL during NTG compared with PLO (BL, 67 ± 10 cm s(−1); PLO, 62 ± 10 cm s(−1); NTG, 59 ± 9.3 cm s(−1), P < 0.05; mean ± SD]. However, total MCA blood flow did not change with NTG or PLO [BL, 221 ± 37.4 ml min(−1); PLO, 218 ± 35.0 ml min(−1); NTG, 213 ± 46.4 ml min(−1)). Therefore, exogenous NO mediates a dilatory response in the rMCA, but not in its downstream vascular bed. John Wiley and Sons Inc. 2018-06-13 2018-08-01 /pmc/articles/PMC6099468/ /pubmed/29766604 http://dx.doi.org/10.1113/EP087022 Text en © 2018 The Authors Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Papers
Schulz, Jenna M.
Al‐Khazraji, Baraa K.
Shoemaker, J. Kevin
Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults
title Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults
title_full Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults
title_fullStr Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults
title_full_unstemmed Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults
title_short Sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults
title_sort sodium nitroglycerin induces middle cerebral artery vasodilatation in young, healthy adults
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099468/
https://www.ncbi.nlm.nih.gov/pubmed/29766604
http://dx.doi.org/10.1113/EP087022
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