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Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site

Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to produce bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases, including cancer. In solid tumors, continuously dividing cells create hypoxic conditions that eventually lead to an acidic mi...

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Detalles Bibliográficos
Autores principales:	Singh, Srishti, Lomelino, Carrie L., Mboge, Mam Y., Frost, Susan C., McKenna, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099549/ https://www.ncbi.nlm.nih.gov/pubmed/29710858 http://dx.doi.org/10.3390/molecules23051045

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