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d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution

The residualizing prosthetic agent N(ε)-(3-[(*)I]iodobenzoyl)-Lys(5)-N(α)-maleimido-Gly(1)-d-GEEEK ([(*)I]IB-Mal-d-GEEEK) showed promise for the radioiodination of monoclonal antibodies (mAbs) that bind to internalizing molecular targets. Although enhanced tumor uptake was achieved in these studies,...

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Detalles Bibliográficos
Autores principales:	Pruszynski, Marek, Kang, Choong Mo, Koumarianou, Eftychia, Vaidyanathan, Ganesan, Zalutsky, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099567/ https://www.ncbi.nlm.nih.gov/pubmed/29783774 http://dx.doi.org/10.3390/molecules23051223

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