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Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations

This study was aimed at formulating a bioabsorbable, controlled-release, nanoemulgel of Quercetin, a potent antimicrobial and anti-inflammatory agent for the treatment of periodontitis that could improve its solubility and bioavailability. Screening of components was carried out based on the solubil...

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Autores principales: Aithal, Gururaj C., Nayak, Usha Yogendra, Mehta, Chetan, Narayan, Reema, Gopalkrishna, Pratibha, Pandiyan, Sudharsan, Garg, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099597/
https://www.ncbi.nlm.nih.gov/pubmed/29882751
http://dx.doi.org/10.3390/molecules23061363
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author Aithal, Gururaj C.
Nayak, Usha Yogendra
Mehta, Chetan
Narayan, Reema
Gopalkrishna, Pratibha
Pandiyan, Sudharsan
Garg, Sanjay
author_facet Aithal, Gururaj C.
Nayak, Usha Yogendra
Mehta, Chetan
Narayan, Reema
Gopalkrishna, Pratibha
Pandiyan, Sudharsan
Garg, Sanjay
author_sort Aithal, Gururaj C.
collection PubMed
description This study was aimed at formulating a bioabsorbable, controlled-release, nanoemulgel of Quercetin, a potent antimicrobial and anti-inflammatory agent for the treatment of periodontitis that could improve its solubility and bioavailability. Screening of components was carried out based on the solubility studies. Nanoemulsion containing cinnamon oil as the oil phase, tween 80 and Carbitol(®) as the surfactant-cosurfactant mixture (S(mix)) and water as the aqueous phase containing 125 µg/200 µL of Quercetin was prepared by using spontaneous emulsification method. Nanoemulgel was prepared using 23% w/v poloxamer 407 as gel base. Comprehensive evaluation of the formulated nanoemulgel was carried out, and the optimized formulation was studied for drug release using Franz vertical diffusion cells. The formulated nanoemulgelexhibited a remarkable release of 92.4% of Quercetin at the end of 6 h, as compared to that of pure Quercetin-loaded gel (<3% release). The viscosity of the prepared nanoemulgel was found to be 30,647 ± 0.32 cPs at 37 °C. Also, molecular dynamics (MD) simulation was utilized to understand the gelation process and role of each component in the formulation. The present study revealed that the developed nanoemulgel of Quercetin could be a potential delivery system for clinical testing in periodontitis.
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spelling pubmed-60995972018-11-13 Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations Aithal, Gururaj C. Nayak, Usha Yogendra Mehta, Chetan Narayan, Reema Gopalkrishna, Pratibha Pandiyan, Sudharsan Garg, Sanjay Molecules Article This study was aimed at formulating a bioabsorbable, controlled-release, nanoemulgel of Quercetin, a potent antimicrobial and anti-inflammatory agent for the treatment of periodontitis that could improve its solubility and bioavailability. Screening of components was carried out based on the solubility studies. Nanoemulsion containing cinnamon oil as the oil phase, tween 80 and Carbitol(®) as the surfactant-cosurfactant mixture (S(mix)) and water as the aqueous phase containing 125 µg/200 µL of Quercetin was prepared by using spontaneous emulsification method. Nanoemulgel was prepared using 23% w/v poloxamer 407 as gel base. Comprehensive evaluation of the formulated nanoemulgel was carried out, and the optimized formulation was studied for drug release using Franz vertical diffusion cells. The formulated nanoemulgelexhibited a remarkable release of 92.4% of Quercetin at the end of 6 h, as compared to that of pure Quercetin-loaded gel (<3% release). The viscosity of the prepared nanoemulgel was found to be 30,647 ± 0.32 cPs at 37 °C. Also, molecular dynamics (MD) simulation was utilized to understand the gelation process and role of each component in the formulation. The present study revealed that the developed nanoemulgel of Quercetin could be a potential delivery system for clinical testing in periodontitis. MDPI 2018-06-04 /pmc/articles/PMC6099597/ /pubmed/29882751 http://dx.doi.org/10.3390/molecules23061363 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aithal, Gururaj C.
Nayak, Usha Yogendra
Mehta, Chetan
Narayan, Reema
Gopalkrishna, Pratibha
Pandiyan, Sudharsan
Garg, Sanjay
Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations
title Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations
title_full Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations
title_fullStr Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations
title_full_unstemmed Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations
title_short Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations
title_sort localized in situ nanoemulgel drug delivery system of quercetin for periodontitis: development and computational simulations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099597/
https://www.ncbi.nlm.nih.gov/pubmed/29882751
http://dx.doi.org/10.3390/molecules23061363
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