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14-3-3: A Case Study in PPI Modulation

In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for p...

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Detalles Bibliográficos
Autores principales: Ballone, Alice, Centorrino, Federica, Ottmann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099619/
https://www.ncbi.nlm.nih.gov/pubmed/29890630
http://dx.doi.org/10.3390/molecules23061386
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author Ballone, Alice
Centorrino, Federica
Ottmann, Christian
author_facet Ballone, Alice
Centorrino, Federica
Ottmann, Christian
author_sort Ballone, Alice
collection PubMed
description In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for pharmacological intervention in human diseases, such as cancer and neurodegenerative and metabolic disorders. This viewpoint is built on the “hub” nature of the 14-3-3 proteins, binding to several hundred identified partners, consequently implicating them in a multitude of different cellular mechanisms. In this review, we provide an overview of the structural and biological features of 14-3-3 and the modulation of 14-3-3 PPIs for discovering small molecular inhibitors and stabilizers of 14-3-3 PPIs.
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spelling pubmed-60996192018-11-13 14-3-3: A Case Study in PPI Modulation Ballone, Alice Centorrino, Federica Ottmann, Christian Molecules Review In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for pharmacological intervention in human diseases, such as cancer and neurodegenerative and metabolic disorders. This viewpoint is built on the “hub” nature of the 14-3-3 proteins, binding to several hundred identified partners, consequently implicating them in a multitude of different cellular mechanisms. In this review, we provide an overview of the structural and biological features of 14-3-3 and the modulation of 14-3-3 PPIs for discovering small molecular inhibitors and stabilizers of 14-3-3 PPIs. MDPI 2018-06-08 /pmc/articles/PMC6099619/ /pubmed/29890630 http://dx.doi.org/10.3390/molecules23061386 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ballone, Alice
Centorrino, Federica
Ottmann, Christian
14-3-3: A Case Study in PPI Modulation
title 14-3-3: A Case Study in PPI Modulation
title_full 14-3-3: A Case Study in PPI Modulation
title_fullStr 14-3-3: A Case Study in PPI Modulation
title_full_unstemmed 14-3-3: A Case Study in PPI Modulation
title_short 14-3-3: A Case Study in PPI Modulation
title_sort 14-3-3: a case study in ppi modulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099619/
https://www.ncbi.nlm.nih.gov/pubmed/29890630
http://dx.doi.org/10.3390/molecules23061386
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