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14-3-3: A Case Study in PPI Modulation
In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for p...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099619/ https://www.ncbi.nlm.nih.gov/pubmed/29890630 http://dx.doi.org/10.3390/molecules23061386 |
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author | Ballone, Alice Centorrino, Federica Ottmann, Christian |
author_facet | Ballone, Alice Centorrino, Federica Ottmann, Christian |
author_sort | Ballone, Alice |
collection | PubMed |
description | In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for pharmacological intervention in human diseases, such as cancer and neurodegenerative and metabolic disorders. This viewpoint is built on the “hub” nature of the 14-3-3 proteins, binding to several hundred identified partners, consequently implicating them in a multitude of different cellular mechanisms. In this review, we provide an overview of the structural and biological features of 14-3-3 and the modulation of 14-3-3 PPIs for discovering small molecular inhibitors and stabilizers of 14-3-3 PPIs. |
format | Online Article Text |
id | pubmed-6099619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60996192018-11-13 14-3-3: A Case Study in PPI Modulation Ballone, Alice Centorrino, Federica Ottmann, Christian Molecules Review In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for pharmacological intervention in human diseases, such as cancer and neurodegenerative and metabolic disorders. This viewpoint is built on the “hub” nature of the 14-3-3 proteins, binding to several hundred identified partners, consequently implicating them in a multitude of different cellular mechanisms. In this review, we provide an overview of the structural and biological features of 14-3-3 and the modulation of 14-3-3 PPIs for discovering small molecular inhibitors and stabilizers of 14-3-3 PPIs. MDPI 2018-06-08 /pmc/articles/PMC6099619/ /pubmed/29890630 http://dx.doi.org/10.3390/molecules23061386 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ballone, Alice Centorrino, Federica Ottmann, Christian 14-3-3: A Case Study in PPI Modulation |
title | 14-3-3: A Case Study in PPI Modulation |
title_full | 14-3-3: A Case Study in PPI Modulation |
title_fullStr | 14-3-3: A Case Study in PPI Modulation |
title_full_unstemmed | 14-3-3: A Case Study in PPI Modulation |
title_short | 14-3-3: A Case Study in PPI Modulation |
title_sort | 14-3-3: a case study in ppi modulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099619/ https://www.ncbi.nlm.nih.gov/pubmed/29890630 http://dx.doi.org/10.3390/molecules23061386 |
work_keys_str_mv | AT ballonealice 1433acasestudyinppimodulation AT centorrinofederica 1433acasestudyinppimodulation AT ottmannchristian 1433acasestudyinppimodulation |