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Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.

Schisandra chinensis (Turcz) Baill. is sufficiently well known as a medicinal plant worldwide, which modern research shows has many pharmacological activities such as hepatoprotective, anti-inflammatory effect, potent anti-HIV-1 activity, anti-tumor effect, and activity on the central nervous system...

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Detalles Bibliográficos
Autores principales: Qiu, Feng, Liu, Han, Duan, Huan, Chen, Pian, Lu, Shao-Juan, Yang, Guang-Zhong, Lei, Xin-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099626/
https://www.ncbi.nlm.nih.gov/pubmed/29973497
http://dx.doi.org/10.3390/molecules23071624
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author Qiu, Feng
Liu, Han
Duan, Huan
Chen, Pian
Lu, Shao-Juan
Yang, Guang-Zhong
Lei, Xin-Xiang
author_facet Qiu, Feng
Liu, Han
Duan, Huan
Chen, Pian
Lu, Shao-Juan
Yang, Guang-Zhong
Lei, Xin-Xiang
author_sort Qiu, Feng
collection PubMed
description Schisandra chinensis (Turcz) Baill. is sufficiently well known as a medicinal plant worldwide, which modern research shows has many pharmacological activities such as hepatoprotective, anti-inflammatory effect, potent anti-HIV-1 activity, anti-tumor effect, and activity on the central nervous system. With considerable chemical investigation, three new triterpenoids (1–3), together with four known triterpenoids were isolated from the S. chinensis (Turcz) Baill. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analyses, single-crystal X-ray diffraction and high-resolution mass spectroscopy, which were identified as Schisanlactone I (1), Schinalactone D, (2), Schisanlactone J, (3) Kadsuphilactone B (4), Schisanlactone C (5), Schisphendilactone B (6), and Schinchinenlactone A (7). The cytotoxicity of those compounds (1–7) was tested against Hep-G2 cell lines, but no apparent antitumor activity was observed at 50 µg/mL using MTT method.
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spelling pubmed-60996262018-11-13 Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill. Qiu, Feng Liu, Han Duan, Huan Chen, Pian Lu, Shao-Juan Yang, Guang-Zhong Lei, Xin-Xiang Molecules Article Schisandra chinensis (Turcz) Baill. is sufficiently well known as a medicinal plant worldwide, which modern research shows has many pharmacological activities such as hepatoprotective, anti-inflammatory effect, potent anti-HIV-1 activity, anti-tumor effect, and activity on the central nervous system. With considerable chemical investigation, three new triterpenoids (1–3), together with four known triterpenoids were isolated from the S. chinensis (Turcz) Baill. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analyses, single-crystal X-ray diffraction and high-resolution mass spectroscopy, which were identified as Schisanlactone I (1), Schinalactone D, (2), Schisanlactone J, (3) Kadsuphilactone B (4), Schisanlactone C (5), Schisphendilactone B (6), and Schinchinenlactone A (7). The cytotoxicity of those compounds (1–7) was tested against Hep-G2 cell lines, but no apparent antitumor activity was observed at 50 µg/mL using MTT method. MDPI 2018-07-04 /pmc/articles/PMC6099626/ /pubmed/29973497 http://dx.doi.org/10.3390/molecules23071624 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qiu, Feng
Liu, Han
Duan, Huan
Chen, Pian
Lu, Shao-Juan
Yang, Guang-Zhong
Lei, Xin-Xiang
Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.
title Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.
title_full Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.
title_fullStr Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.
title_full_unstemmed Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.
title_short Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.
title_sort isolation, structural elucidation of three new triterpenoids from the stems and leaves of schisandra chinensis (turcz) baill.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099626/
https://www.ncbi.nlm.nih.gov/pubmed/29973497
http://dx.doi.org/10.3390/molecules23071624
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