Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy

Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently availabl...

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Autores principales: Sun, Jingyao, Kormakov, Semen, Liu, Ying, Huang, Yao, Wu, Daming, Yang, Zhaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099795/
https://www.ncbi.nlm.nih.gov/pubmed/30002333
http://dx.doi.org/10.3390/molecules23071704
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author Sun, Jingyao
Kormakov, Semen
Liu, Ying
Huang, Yao
Wu, Daming
Yang, Zhaogang
author_facet Sun, Jingyao
Kormakov, Semen
Liu, Ying
Huang, Yao
Wu, Daming
Yang, Zhaogang
author_sort Sun, Jingyao
collection PubMed
description Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.
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spelling pubmed-60997952018-11-13 Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy Sun, Jingyao Kormakov, Semen Liu, Ying Huang, Yao Wu, Daming Yang, Zhaogang Molecules Review Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed. MDPI 2018-07-12 /pmc/articles/PMC6099795/ /pubmed/30002333 http://dx.doi.org/10.3390/molecules23071704 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Jingyao
Kormakov, Semen
Liu, Ying
Huang, Yao
Wu, Daming
Yang, Zhaogang
Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_full Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_fullStr Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_full_unstemmed Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_short Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy
title_sort recent progress in metal-based nanoparticles mediated photodynamic therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099795/
https://www.ncbi.nlm.nih.gov/pubmed/30002333
http://dx.doi.org/10.3390/molecules23071704
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