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Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple

Ultra-performance convergence chromatography is an environmentally-friendly analytical method that uses dramatically reduced amounts of organic solvents. In addition, a robust and highly sensitive chiral separation method was developed for the novel chiral acaricide cyflumetofen by using ultra-perfo...

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Autores principales: Guo, Jing, Li, Minmin, Liu, Yongguo, Wang, Fengzhong, Kong, Zhiqiang, Sun, Yufeng, Lu, Jia, Jin, Nuo, Huang, Yatao, Liu, Jiameng, Francis, Frédéric, Fan, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099807/
https://www.ncbi.nlm.nih.gov/pubmed/29724046
http://dx.doi.org/10.3390/molecules23051060
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author Guo, Jing
Li, Minmin
Liu, Yongguo
Wang, Fengzhong
Kong, Zhiqiang
Sun, Yufeng
Lu, Jia
Jin, Nuo
Huang, Yatao
Liu, Jiameng
Francis, Frédéric
Fan, Bei
author_facet Guo, Jing
Li, Minmin
Liu, Yongguo
Wang, Fengzhong
Kong, Zhiqiang
Sun, Yufeng
Lu, Jia
Jin, Nuo
Huang, Yatao
Liu, Jiameng
Francis, Frédéric
Fan, Bei
author_sort Guo, Jing
collection PubMed
description Ultra-performance convergence chromatography is an environmentally-friendly analytical method that uses dramatically reduced amounts of organic solvents. In addition, a robust and highly sensitive chiral separation method was developed for the novel chiral acaricide cyflumetofen by using ultra-performance convergence chromatography coupled with tandem mass spectrometry, which shows that stereoisomer recoveries determined for various apple parts ranged from 78.3% to 119.9%, with the relative standard deviations being lower than 14.0%. The half-lives of (−)-cyflumetofen and (+)-cyflumetofen obtained under 5-fold applied dosage equal to 22.13 and 22.23 days, respectively. For 1.5-fold applied dosage, the respective values were determined as 22.42 and 23.64 days, i.e., the degradation of (−)-cyflumetofen was insignificantly favored over that of its enantiomer. Importantly, cyflumetofen was unevenly distributed in apples, with its relative contents in apple peel, peduncle, and pomace equal to 50%, 22%, and 16%, respectively. The proposed method can be used to efficiently separate and quantify chiral pesticide with advantages of a shorter analysis time, greater sensitivity, and better environmental compatibility. Additionally, the consumption of apples with residue of cyflumetofen did not pose a health risk to the population if the cyflumetofen applied under satisfactory agricultural practices after the long-term dietary risk assessment.
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spelling pubmed-60998072018-11-13 Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple Guo, Jing Li, Minmin Liu, Yongguo Wang, Fengzhong Kong, Zhiqiang Sun, Yufeng Lu, Jia Jin, Nuo Huang, Yatao Liu, Jiameng Francis, Frédéric Fan, Bei Molecules Article Ultra-performance convergence chromatography is an environmentally-friendly analytical method that uses dramatically reduced amounts of organic solvents. In addition, a robust and highly sensitive chiral separation method was developed for the novel chiral acaricide cyflumetofen by using ultra-performance convergence chromatography coupled with tandem mass spectrometry, which shows that stereoisomer recoveries determined for various apple parts ranged from 78.3% to 119.9%, with the relative standard deviations being lower than 14.0%. The half-lives of (−)-cyflumetofen and (+)-cyflumetofen obtained under 5-fold applied dosage equal to 22.13 and 22.23 days, respectively. For 1.5-fold applied dosage, the respective values were determined as 22.42 and 23.64 days, i.e., the degradation of (−)-cyflumetofen was insignificantly favored over that of its enantiomer. Importantly, cyflumetofen was unevenly distributed in apples, with its relative contents in apple peel, peduncle, and pomace equal to 50%, 22%, and 16%, respectively. The proposed method can be used to efficiently separate and quantify chiral pesticide with advantages of a shorter analysis time, greater sensitivity, and better environmental compatibility. Additionally, the consumption of apples with residue of cyflumetofen did not pose a health risk to the population if the cyflumetofen applied under satisfactory agricultural practices after the long-term dietary risk assessment. MDPI 2018-05-02 /pmc/articles/PMC6099807/ /pubmed/29724046 http://dx.doi.org/10.3390/molecules23051060 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Jing
Li, Minmin
Liu, Yongguo
Wang, Fengzhong
Kong, Zhiqiang
Sun, Yufeng
Lu, Jia
Jin, Nuo
Huang, Yatao
Liu, Jiameng
Francis, Frédéric
Fan, Bei
Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple
title Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple
title_full Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple
title_fullStr Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple
title_full_unstemmed Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple
title_short Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple
title_sort residue and dietary risk assessment of chiral cyflumetofen in apple
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099807/
https://www.ncbi.nlm.nih.gov/pubmed/29724046
http://dx.doi.org/10.3390/molecules23051060
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