Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work con...

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Detalles Bibliográficos
Autores principales: Barré, Baptiste, Gonnard, Laurine, Guérinot, Amandine, Cossy, Janine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099817/
https://www.ncbi.nlm.nih.gov/pubmed/29904007
http://dx.doi.org/10.3390/molecules23061449
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author Barré, Baptiste
Gonnard, Laurine
Guérinot, Amandine
Cossy, Janine
author_facet Barré, Baptiste
Gonnard, Laurine
Guérinot, Amandine
Cossy, Janine
author_sort Barré, Baptiste
collection PubMed
description (Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented.
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spelling pubmed-60998172018-11-13 Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents Barré, Baptiste Gonnard, Laurine Guérinot, Amandine Cossy, Janine Molecules Review (Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these attractive scaffolds. An overview of our work concerning the cobalt-catalyzed arylation of iodo-substituted cyclic amines is presented. MDPI 2018-06-14 /pmc/articles/PMC6099817/ /pubmed/29904007 http://dx.doi.org/10.3390/molecules23061449 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Barré, Baptiste
Gonnard, Laurine
Guérinot, Amandine
Cossy, Janine
Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
title Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
title_full Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
title_fullStr Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
title_full_unstemmed Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
title_short Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
title_sort cobalt-catalyzed (hetero)arylation of saturated cyclic amines with grignard reagents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099817/
https://www.ncbi.nlm.nih.gov/pubmed/29904007
http://dx.doi.org/10.3390/molecules23061449
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AT gonnardlaurine cobaltcatalyzedheteroarylationofsaturatedcyclicamineswithgrignardreagents
AT guerinotamandine cobaltcatalyzedheteroarylationofsaturatedcyclicamineswithgrignardreagents
AT cossyjanine cobaltcatalyzedheteroarylationofsaturatedcyclicamineswithgrignardreagents

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