Synthesis of 8-Fluoro-3,4-dihydroisoquinoline and Its Transformation to 1,8-Disubstituted Tetrahydroisoquinolines

A simple procedure for the synthesis of 8-fluoro-3,4-dihydroisoquinoline is described below, based on a directed ortho-lithiation reaction. This key intermediate was then applied in various transformations. Fluorine–amine exchange afforded the corresponding 8-amino-3,4-dihydroisoquinolines, suitable...

Descripción completa

Detalles Bibliográficos
Autores principales: Hargitai, Csilla, Nagy, Tamás, Halász, Judit, Simig, Gyula, Volk, Balázs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099844/
https://www.ncbi.nlm.nih.gov/pubmed/29861464
http://dx.doi.org/10.3390/molecules23061280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099844/
https://www.ncbi.nlm.nih.gov/pubmed/29861464
http://dx.doi.org/10.3390/molecules23061280

Ejemplares similares