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Bioactive Indanes: Proof of Concept Study for Enantioselective Synthetic Routes to PH46A, a New Potential Anti-Inflammatory Agent

PH46A is a single enantiomer and a member of the 1,2-indane dimer family. It has two contiguous stereogenic centers with S,S configurations, one of which being a quaternary center, which has been developed as a clinical candidate for the treatment of inflammatory and autoimmune conditions. The curre...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Scalabrino, Gaia, Frankish, Neil, Sheridan, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099954/
https://www.ncbi.nlm.nih.gov/pubmed/29933592
http://dx.doi.org/10.3390/molecules23071503