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Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats

The present study used isometric tension recording to investigate the vasorelaxant effect of limonene (LM), carveol (CV), and perillyl alcohol (POH) on contractility parameters of the rat aorta, focusing in particular on the structure-activity relationship. LM, CV, and POH showed a reversible inhibi...

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Autores principales: Cardoso-Teixeira, Ana Carolina, Ferreira-da-Silva, Francisco Walber, Peixoto-Neves, Dieniffer, Oliveira-Abreu, Klausen, Pereira-Gonçalves, Átila, Coelho-de-Souza, Andrelina Noronha, Leal-Cardoso, José Henrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099955/
https://www.ncbi.nlm.nih.gov/pubmed/29899230
http://dx.doi.org/10.3390/molecules23061430
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author Cardoso-Teixeira, Ana Carolina
Ferreira-da-Silva, Francisco Walber
Peixoto-Neves, Dieniffer
Oliveira-Abreu, Klausen
Pereira-Gonçalves, Átila
Coelho-de-Souza, Andrelina Noronha
Leal-Cardoso, José Henrique
author_facet Cardoso-Teixeira, Ana Carolina
Ferreira-da-Silva, Francisco Walber
Peixoto-Neves, Dieniffer
Oliveira-Abreu, Klausen
Pereira-Gonçalves, Átila
Coelho-de-Souza, Andrelina Noronha
Leal-Cardoso, José Henrique
author_sort Cardoso-Teixeira, Ana Carolina
collection PubMed
description The present study used isometric tension recording to investigate the vasorelaxant effect of limonene (LM), carveol (CV), and perillyl alcohol (POH) on contractility parameters of the rat aorta, focusing in particular on the structure-activity relationship. LM, CV, and POH showed a reversible inhibitory effect on the contraction induced by electromechanical and pharmacomechanical coupling. In the case of LM, but not CV and POH, this effect was influenced by preservation of the endothelium. POH and CV but not LM exhibited greater pharmacological potency on BayK-8644-induced contraction and on electromechanical coupling than on pharmacomechanical coupling. In endothelium-denuded preparations, the order of pharmacological potency on electrochemical coupling was LM < CV < POH. These compounds inhibited also, with grossly similar pharmacological potency, the contraction induced by phorbol ester dibutyrate. The present results suggest that LM, CV and POH induced relaxant effect on vascular smooth muscle by means of different mechanisms likely to include inhibition of PKC and IP3 pathway. For CV and POH, hydroxylated compounds, it was in electromechanical coupling that the greater pharmacological potency was observed, thus suggesting a relative specificity for a mechanism likely to be important in electromechanical coupling, for example, blockade of voltage-dependent calcium channel.
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spelling pubmed-60999552018-11-13 Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats Cardoso-Teixeira, Ana Carolina Ferreira-da-Silva, Francisco Walber Peixoto-Neves, Dieniffer Oliveira-Abreu, Klausen Pereira-Gonçalves, Átila Coelho-de-Souza, Andrelina Noronha Leal-Cardoso, José Henrique Molecules Article The present study used isometric tension recording to investigate the vasorelaxant effect of limonene (LM), carveol (CV), and perillyl alcohol (POH) on contractility parameters of the rat aorta, focusing in particular on the structure-activity relationship. LM, CV, and POH showed a reversible inhibitory effect on the contraction induced by electromechanical and pharmacomechanical coupling. In the case of LM, but not CV and POH, this effect was influenced by preservation of the endothelium. POH and CV but not LM exhibited greater pharmacological potency on BayK-8644-induced contraction and on electromechanical coupling than on pharmacomechanical coupling. In endothelium-denuded preparations, the order of pharmacological potency on electrochemical coupling was LM < CV < POH. These compounds inhibited also, with grossly similar pharmacological potency, the contraction induced by phorbol ester dibutyrate. The present results suggest that LM, CV and POH induced relaxant effect on vascular smooth muscle by means of different mechanisms likely to include inhibition of PKC and IP3 pathway. For CV and POH, hydroxylated compounds, it was in electromechanical coupling that the greater pharmacological potency was observed, thus suggesting a relative specificity for a mechanism likely to be important in electromechanical coupling, for example, blockade of voltage-dependent calcium channel. MDPI 2018-06-13 /pmc/articles/PMC6099955/ /pubmed/29899230 http://dx.doi.org/10.3390/molecules23061430 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cardoso-Teixeira, Ana Carolina
Ferreira-da-Silva, Francisco Walber
Peixoto-Neves, Dieniffer
Oliveira-Abreu, Klausen
Pereira-Gonçalves, Átila
Coelho-de-Souza, Andrelina Noronha
Leal-Cardoso, José Henrique
Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats
title Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats
title_full Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats
title_fullStr Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats
title_full_unstemmed Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats
title_short Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats
title_sort hydroxyl group and vasorelaxant effects of perillyl alcohol, carveol, limonene on aorta smooth muscle of rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099955/
https://www.ncbi.nlm.nih.gov/pubmed/29899230
http://dx.doi.org/10.3390/molecules23061430
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