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Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats

Pre-diabetes is a condition that precedes type 2 diabetes mellitus (T2DM) that is characterised by elevated glycated haemoglobin (HbA1c). The management of pre-diabetes includes the combination of dietary and pharmacological interventions to increase insulin sensitivity. However, poor patient compli...

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Autores principales: Mabuza, Lindokuhle Patience, Gamede, Mlindeli Wilkinson, Maikoo, Sanam, Booysen, Irvin Noel, Ngubane, Phikelelani Siphosethu, Khathi, Andile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100054/
https://www.ncbi.nlm.nih.gov/pubmed/30011905
http://dx.doi.org/10.3390/molecules23071721
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author Mabuza, Lindokuhle Patience
Gamede, Mlindeli Wilkinson
Maikoo, Sanam
Booysen, Irvin Noel
Ngubane, Phikelelani Siphosethu
Khathi, Andile
author_facet Mabuza, Lindokuhle Patience
Gamede, Mlindeli Wilkinson
Maikoo, Sanam
Booysen, Irvin Noel
Ngubane, Phikelelani Siphosethu
Khathi, Andile
author_sort Mabuza, Lindokuhle Patience
collection PubMed
description Pre-diabetes is a condition that precedes type 2 diabetes mellitus (T2DM) that is characterised by elevated glycated haemoglobin (HbA1c). The management of pre-diabetes includes the combination of dietary and pharmacological interventions to increase insulin sensitivity. However, poor patient compliance has been reported with regard to dietary interventions, therefore, new alternative drugs are required that can be effective even without the dietary intervention. In our laboratory, we have synthesised a novel ruthenium complex that has been shown to have elevated biological activity. This study investigated the effects of this complex in both the presence and absence of dietary intervention on glucose handling in a diet-induced pre-diabetes rat model. Pre-diabetic animals were randomly assigned to respective treatment groups. The ruthenium complex was administered to pre-diabetic rats once a day every third day for 12 weeks. The administration of the ruthenium complex resulted in reduced fasting blood glucose, food intake, and body weight gain which was associated with decreased plasma ghrelin, insulin, and HbA1c levels in both the presence and absence of dietary intervention. The administration of the ruthenium complex ameliorated glycaemic control and insulin sensitivity in pre-diabetic rats. The results of this study warrant further investigations as this compound could potentially be able to re-sensitize insulin resistant cells and reduce the incidence of T2DM.
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spelling pubmed-61000542018-11-13 Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats Mabuza, Lindokuhle Patience Gamede, Mlindeli Wilkinson Maikoo, Sanam Booysen, Irvin Noel Ngubane, Phikelelani Siphosethu Khathi, Andile Molecules Article Pre-diabetes is a condition that precedes type 2 diabetes mellitus (T2DM) that is characterised by elevated glycated haemoglobin (HbA1c). The management of pre-diabetes includes the combination of dietary and pharmacological interventions to increase insulin sensitivity. However, poor patient compliance has been reported with regard to dietary interventions, therefore, new alternative drugs are required that can be effective even without the dietary intervention. In our laboratory, we have synthesised a novel ruthenium complex that has been shown to have elevated biological activity. This study investigated the effects of this complex in both the presence and absence of dietary intervention on glucose handling in a diet-induced pre-diabetes rat model. Pre-diabetic animals were randomly assigned to respective treatment groups. The ruthenium complex was administered to pre-diabetic rats once a day every third day for 12 weeks. The administration of the ruthenium complex resulted in reduced fasting blood glucose, food intake, and body weight gain which was associated with decreased plasma ghrelin, insulin, and HbA1c levels in both the presence and absence of dietary intervention. The administration of the ruthenium complex ameliorated glycaemic control and insulin sensitivity in pre-diabetic rats. The results of this study warrant further investigations as this compound could potentially be able to re-sensitize insulin resistant cells and reduce the incidence of T2DM. MDPI 2018-07-14 /pmc/articles/PMC6100054/ /pubmed/30011905 http://dx.doi.org/10.3390/molecules23071721 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mabuza, Lindokuhle Patience
Gamede, Mlindeli Wilkinson
Maikoo, Sanam
Booysen, Irvin Noel
Ngubane, Phikelelani Siphosethu
Khathi, Andile
Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats
title Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats
title_full Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats
title_fullStr Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats
title_full_unstemmed Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats
title_short Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats
title_sort effects of a ruthenium schiff base complex on glucose homeostasis in diet-induced pre-diabetic rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100054/
https://www.ncbi.nlm.nih.gov/pubmed/30011905
http://dx.doi.org/10.3390/molecules23071721
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