Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity

In this study, a series of novel pyrazole-hydrazone derivatives containing an isoxazole moiety were synthesized. Antiviral bioassays indicated that some of the title compounds exhibited better in vivo antiviral activities against tobacco mosaic virus (TMV). In particular, compounds 6a, 6c and 6q exh...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Zaibo, Li, Pei, Gan, Xiuhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100116/
https://www.ncbi.nlm.nih.gov/pubmed/30037021
http://dx.doi.org/10.3390/molecules23071798
_version_ 1783348805942378496
author Yang, Zaibo
Li, Pei
Gan, Xiuhai
author_facet Yang, Zaibo
Li, Pei
Gan, Xiuhai
author_sort Yang, Zaibo
collection PubMed
description In this study, a series of novel pyrazole-hydrazone derivatives containing an isoxazole moiety were synthesized. Antiviral bioassays indicated that some of the title compounds exhibited better in vivo antiviral activities against tobacco mosaic virus (TMV). In particular, compounds 6a, 6c and 6q exhibited the best curative activity, protection activity, and inactivation activity against TMV, respectively, which were superior to those of Ningnanmycin. This study demonstrated that this series of novel pyrazole-hydrazone derivatives containing an isoxazole amide moiety could effectively control TMV.
format Online
Article
Text
id pubmed-6100116
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61001162018-11-13 Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity Yang, Zaibo Li, Pei Gan, Xiuhai Molecules Article In this study, a series of novel pyrazole-hydrazone derivatives containing an isoxazole moiety were synthesized. Antiviral bioassays indicated that some of the title compounds exhibited better in vivo antiviral activities against tobacco mosaic virus (TMV). In particular, compounds 6a, 6c and 6q exhibited the best curative activity, protection activity, and inactivation activity against TMV, respectively, which were superior to those of Ningnanmycin. This study demonstrated that this series of novel pyrazole-hydrazone derivatives containing an isoxazole amide moiety could effectively control TMV. MDPI 2018-07-20 /pmc/articles/PMC6100116/ /pubmed/30037021 http://dx.doi.org/10.3390/molecules23071798 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Zaibo
Li, Pei
Gan, Xiuhai
Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity
title Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity
title_full Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity
title_fullStr Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity
title_full_unstemmed Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity
title_short Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity
title_sort novel pyrazole-hydrazone derivatives containing an isoxazole moiety: design, synthesis, and antiviral activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100116/
https://www.ncbi.nlm.nih.gov/pubmed/30037021
http://dx.doi.org/10.3390/molecules23071798
work_keys_str_mv AT yangzaibo novelpyrazolehydrazonederivativescontaininganisoxazolemoietydesignsynthesisandantiviralactivity
AT lipei novelpyrazolehydrazonederivativescontaininganisoxazolemoietydesignsynthesisandantiviralactivity
AT ganxiuhai novelpyrazolehydrazonederivativescontaininganisoxazolemoietydesignsynthesisandantiviralactivity

Ejemplares similares