Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity

Seven new triterpenoid saponins (1–7), together with three known ones (8–10), were isolated from Ilex pubescens. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrared spectra (IR), and nuclear magnetic resonance (NMR) s...

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Autores principales: Qiao, Xiaoxu, Ji, Mengying, Yao, Yunda, Ma, Leilei, Wu, Jinjun, Liao, Guochao, Zhou, Hua, Liu, Zhongqiu, Wu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100132/
https://www.ncbi.nlm.nih.gov/pubmed/29895796
http://dx.doi.org/10.3390/molecules23061426
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author Qiao, Xiaoxu
Ji, Mengying
Yao, Yunda
Ma, Leilei
Wu, Jinjun
Liao, Guochao
Zhou, Hua
Liu, Zhongqiu
Wu, Peng
author_facet Qiao, Xiaoxu
Ji, Mengying
Yao, Yunda
Ma, Leilei
Wu, Jinjun
Liao, Guochao
Zhou, Hua
Liu, Zhongqiu
Wu, Peng
author_sort Qiao, Xiaoxu
collection PubMed
description Seven new triterpenoid saponins (1–7), together with three known ones (8–10), were isolated from Ilex pubescens. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrared spectra (IR), and nuclear magnetic resonance (NMR) spectroscopic data. The anti-inflammatory activity of the isolates toward lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages was investigated. The results demonstrated that compounds 3, 5, and 6 inhibited the expression of inducible nitric oxide synthase (iNOS) protein in comparison with LPS stimulation in RAW264.7 cells.
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spelling pubmed-61001322018-11-13 Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity Qiao, Xiaoxu Ji, Mengying Yao, Yunda Ma, Leilei Wu, Jinjun Liao, Guochao Zhou, Hua Liu, Zhongqiu Wu, Peng Molecules Article Seven new triterpenoid saponins (1–7), together with three known ones (8–10), were isolated from Ilex pubescens. Elucidation of their structures was performed based on high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS), infrared spectra (IR), and nuclear magnetic resonance (NMR) spectroscopic data. The anti-inflammatory activity of the isolates toward lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages was investigated. The results demonstrated that compounds 3, 5, and 6 inhibited the expression of inducible nitric oxide synthase (iNOS) protein in comparison with LPS stimulation in RAW264.7 cells. MDPI 2018-06-12 /pmc/articles/PMC6100132/ /pubmed/29895796 http://dx.doi.org/10.3390/molecules23061426 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qiao, Xiaoxu
Ji, Mengying
Yao, Yunda
Ma, Leilei
Wu, Jinjun
Liao, Guochao
Zhou, Hua
Liu, Zhongqiu
Wu, Peng
Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity
title Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity
title_full Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity
title_fullStr Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity
title_full_unstemmed Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity
title_short Pubescenosides E–K, Seven New Triterpenoid Saponins from the Roots of Ilex pubescens and Their Anti-Inflammatory Activity
title_sort pubescenosides e–k, seven new triterpenoid saponins from the roots of ilex pubescens and their anti-inflammatory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100132/
https://www.ncbi.nlm.nih.gov/pubmed/29895796
http://dx.doi.org/10.3390/molecules23061426
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