Cargando…

Discovery of Flavonoids from Scutellaria baicalensis with Inhibitory Activity Against PCSK 9 Expression: Isolation, Synthesis and Their Biological Evaluation

Nine flavonoids were isolated and identified from a chloroform-soluble fraction of the roots of Scutellaria baicalensis through a bioactivity-guided fractionation using a proprotein convertase subtilisin/kexin type 9 (PCSK9) monitoring assay in HepG2 cells. All structures were established by interpr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nhoek, Piseth, Chae, Hee-Sung, Masagalli, Jagadeesh Nagarajappa, Mailar, Karabasappa, Pel, Pisey, Kim, Young-Mi, Choi, Won Jun, Chin, Young-Won
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100156/ https://www.ncbi.nlm.nih.gov/pubmed/29495284 http://dx.doi.org/10.3390/molecules23020504

Ejemplares similares

Ruthenium Chloride—Induced Oxidative Cyclization of Trans-Resveratrol to (±)-ε-Viniferin and Antimicrobial and Antibiofilm Activity Against Streptococcus pneumoniae
por: Yadav, Mukesh Kumar, et al.
Publicado: (2019)

Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells
por: Masagalli, Jagadeesh Nagarajappa, et al.
Publicado: (2021)

Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
por: Pei, Tianlin, et al.
Publicado: (2022)

Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression
por: Pel, Pisey, et al.
Publicado: (2022)

Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris
por: Pel, Pisey, et al.
Publicado: (2022)

Comparative Genome Analysis of Scutellaria baicalensis and Scutellaria barbata Reveals the Evolution of Active Flavonoid Biosynthesis
por: Xu, Zhichao, et al.
Publicado: (2020)

Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction
por: Im, A-Rang, et al.
Publicado: (2012)

A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis
por: Wang, Zi-Long, et al.
Publicado: (2018)

Flavonoids from Scutellaria baicalensis Georgi are effective to treat cerebral ischemia/reperfusion
por: Shang, Yazhen, et al.
Publicado: (2013)

The Flavonoid Components of Scutellaria baicalensis: Biopharmaceutical Properties and their Improvement using Nanoformulation Techniques
por: Wang, Jilin, et al.
Publicado: (2023)

EST sequencing and gene expression profiling in Scutellaria baicalensis
por: Park, Nam Il, et al.
Publicado: (2014)

Organ-Specific Metabolic Shifts of Flavonoids in Scutellaria baicalensis at Different Growth and Development Stages
por: Xu, Jingyuan, et al.
Publicado: (2018)

The cultivable endophytic fungal community of Scutellaria baicalensis: diversity and relevance to flavonoid production by the host
por: Cui, Xiao-Xuan, et al.
Publicado: (2022)

Scutellaria baicalensis Georgi and Their Natural Flavonoid Compounds in the Treatment of Ovarian Cancer: A Review
por: Cai, Jiaying, et al.
Publicado: (2023)

Natural Deep Eutectic Solvent Extraction of Flavonoids of Scutellaria baicalensis as a Replacement for Conventional Organic Solvents
por: Oomen, Wim Wouter, et al.
Publicado: (2020)

In vivo therapeutic effect of combination treatment with metformin and Scutellaria baicalensis on maintaining bile acid homeostasis
por: Han, Kyungsun, et al.
Publicado: (2017)

Pretreatment with scutellaria baicalensis stem-leaf total flavonoid prevents cerebral ischemia-reperfusion injury
por: Zhao, Shumin, et al.
Publicado: (2013)

Water Deficit Affected Flavonoid Accumulation by Regulating Hormone Metabolism in Scutellaria baicalensis Georgi Roots
por: Yuan, Yuan, et al.
Publicado: (2012)

Optimization of the extraction of total flavonoids from Scutellaria baicalensis Georgi using the response surface methodology
por: Liu, Yanqing, et al.
Publicado: (2014)

Electrostimulation improves plant growth and modulates the flavonoid profile in aeroponic culture of Scutellaria baicalensis Georgi
por: Grzelka, Kajetan, et al.
Publicado: (2023)

Scutellaria baicalensis decreases ritonavir-induced nausea
por: Aung, Han, et al.
Publicado: (2005)

Prenylated Flavonoid Glycosides with PCSK9 mRNA Expression Inhibitory Activity from the Aerial Parts of Epimedium koreanum
por: Kim, Eeray, et al.
Publicado: (2021)

Korean Scutellaria baicalensis Georgi flavonoid extract induces mitochondrially mediated apoptosis in human gastric cancer AGS cells
por: Venkatarame Gowda Saralamma, Venu, et al.
Publicado: (2017)

Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats
por: Song, Jungbin, et al.
Publicado: (2020)

Extract of Scutellaria baicalensis inhibits dengue virus replication
por: Zandi, Keivan, et al.
Publicado: (2013)

Quantification of propionic acid from Scutellaria baicalensis roots
por: Son, Eunjung, et al.
Publicado: (2017)

Separation methods used for Scutellaria baicalensis active components
por: Li, Hua-Bin, et al.
Publicado: (2004)

Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica
por: Kim, Sang Won, et al.
Publicado: (2013)

Deep Sequencing of the Scutellaria baicalensis Georgi Transcriptome Reveals Flavonoid Biosynthetic Profiling and Organ-Specific Gene Expression
por: Liu, Jinxin, et al.
Publicado: (2015)

Characterization of UDP-glycosyltransferase family members reveals how major flavonoid glycoside accumulates in the roots of Scutellaria baicalensis
por: Pei, Tianlin, et al.
Publicado: (2022)

Proteome profiling of lipopolysaccharide induced L6 rat skeletal muscle cells response to flavonoids from Scutellaria baicalensis Georgi
por: Kim, Jin A, et al.
Publicado: (2014)

Scutellaria baicalensis Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice
por: Seo, Ho-won, et al.
Publicado: (2023)

Three new lignan glucosides from the roots of Scutellaria baicalensis
por: Long, Hailin, et al.
Publicado: (2016)

Effects of Chilling Treatment on Baicalin, Baicalein, and Wogonin Biosynthesis in Scutellaria baicalensis Plantlets
por: Yeo, Hyeon Ji, et al.
Publicado: (2022)

Scutellaria baicalensis Alleviates Insulin Resistance in Diet-Induced Obese Mice by Modulating Inflammation
por: Na, Hyun-Young, et al.
Publicado: (2019)

Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway
por: WANG, CHONG-ZHI, et al.
Publicado: (2013)

Scutellaria baicalensis stem-leaf total flavonoid reduces neuronal apoptosis induced by amyloid beta-peptide (25–35)☆
por: Wang, Ruiting, et al.
Publicado: (2013)

Mechanisms underlying attenuation of apoptosis of cortical neurons in the hypoxic brain by flavonoids from the stems and leaves of Scutellaria baicalensis Georgi
por: Miao, Guangxin, et al.
Publicado: (2014)

Pretreatment with scutellaria baicalensis stem-leaf total flavonoid protects against cerebral ischemia/reperfusion injury in hippocampal neurons
por: Kong, Xiangyu, et al.
Publicado: (2014)

The Chloroplast Genome Sequence of Scutellaria baicalensis Provides Insight into Intraspecific and Interspecific Chloroplast Genome Diversity in Scutellaria
por: Jiang, Dan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_uvl1dloecphucls9n1hu6tcbs7