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Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans
The objective of this study was to investigate the relationship between the extent of emphysema and heart size in patients with chronic obstructive pulmonary disease (COPD) using inspiratory and expiratory chest computed tomography (CT). This retrospective study was approved by the institutional rev...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100166/ https://www.ncbi.nlm.nih.gov/pubmed/29141441 http://dx.doi.org/10.1177/1479972317741896 |
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author | Tomita, Hayato Yamashiro, Tsuneo Matsuoka, Shin Matsushita, Shoichiro Nakajima, Yasuo |
author_facet | Tomita, Hayato Yamashiro, Tsuneo Matsuoka, Shin Matsushita, Shoichiro Nakajima, Yasuo |
author_sort | Tomita, Hayato |
collection | PubMed |
description | The objective of this study was to investigate the relationship between the extent of emphysema and heart size in patients with chronic obstructive pulmonary disease (COPD) using inspiratory and expiratory chest computed tomography (CT). This retrospective study was approved by the institutional review board and informed consent was waived. We measured lung volume (LV), low attenuation area percent (%LAA; less than or equal to −950 HU), maximum cardiac area, and maximum transverse cardiac diameter on inspiratory/expiratory chest CT in 60 patients with COPD. Spearman rank correlation analysis was used to determine the correlations between the heart and lung CT measurements, and the correlations between these measurements and spirometric values. On inspiratory CT, the maximum transverse cardiac diameter was negatively correlated with LV (ρ = −0.42; p < 0.01) and %LAA (ρ = −0.43; p < 0.001). Furthermore, on expiratory CT, the maximum cardiac area was negatively correlated with LV (ρ = −0.35; p < 0.01) and %LAA (ρ = −0.37; p < 0.01), and there was a negative correlation between transverse cardiac diameter and %LAA (ρ = −0.34; p < 0.01). Although inspiratory cardiac size was not correlated with any of the spirometric values, the maximum cardiac area and transverse diameter on expiratory scans were significantly correlated with the reduced airflow values on spirometry (p < 0.01). In patients with COPD, the transverse cardiac diameter decreased as the emphysema progressed. A smaller cardiac area on expiratory CT suggested the presence of large LVs, emphysema, and airflow limitation in COPD. |
format | Online Article Text |
id | pubmed-6100166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-61001662018-08-24 Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans Tomita, Hayato Yamashiro, Tsuneo Matsuoka, Shin Matsushita, Shoichiro Nakajima, Yasuo Chron Respir Dis Original Papers The objective of this study was to investigate the relationship between the extent of emphysema and heart size in patients with chronic obstructive pulmonary disease (COPD) using inspiratory and expiratory chest computed tomography (CT). This retrospective study was approved by the institutional review board and informed consent was waived. We measured lung volume (LV), low attenuation area percent (%LAA; less than or equal to −950 HU), maximum cardiac area, and maximum transverse cardiac diameter on inspiratory/expiratory chest CT in 60 patients with COPD. Spearman rank correlation analysis was used to determine the correlations between the heart and lung CT measurements, and the correlations between these measurements and spirometric values. On inspiratory CT, the maximum transverse cardiac diameter was negatively correlated with LV (ρ = −0.42; p < 0.01) and %LAA (ρ = −0.43; p < 0.001). Furthermore, on expiratory CT, the maximum cardiac area was negatively correlated with LV (ρ = −0.35; p < 0.01) and %LAA (ρ = −0.37; p < 0.01), and there was a negative correlation between transverse cardiac diameter and %LAA (ρ = −0.34; p < 0.01). Although inspiratory cardiac size was not correlated with any of the spirometric values, the maximum cardiac area and transverse diameter on expiratory scans were significantly correlated with the reduced airflow values on spirometry (p < 0.01). In patients with COPD, the transverse cardiac diameter decreased as the emphysema progressed. A smaller cardiac area on expiratory CT suggested the presence of large LVs, emphysema, and airflow limitation in COPD. SAGE Publications 2017-11-15 2018-08 /pmc/articles/PMC6100166/ /pubmed/29141441 http://dx.doi.org/10.1177/1479972317741896 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Papers Tomita, Hayato Yamashiro, Tsuneo Matsuoka, Shin Matsushita, Shoichiro Nakajima, Yasuo Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans |
title | Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans |
title_full | Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans |
title_fullStr | Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans |
title_full_unstemmed | Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans |
title_short | Correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: CT-based analysis using inspiratory and expiratory scans |
title_sort | correlation between heart size and emphysema in patients with chronic obstructive pulmonary disease: ct-based analysis using inspiratory and expiratory scans |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100166/ https://www.ncbi.nlm.nih.gov/pubmed/29141441 http://dx.doi.org/10.1177/1479972317741896 |
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