Cargando…

β-Phenylalanine Ester Synthesis from Stable β-Keto Ester Substrate Using Engineered ω-Transaminases

The successful synthesis of chiral amines from ketones using ω-transaminases has been shown in many cases in the last two decades. In contrast, the amination of β-keto acids is a special and relatively new challenge, as they decompose easily in aqueous solution. To avoid this, transamination of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buß, Oliver, Voss, Moritz, Delavault, André, Gorenflo, Pascal, Syldatk, Christoph, Bornscheuer, Uwe, Rudat, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100204/ https://www.ncbi.nlm.nih.gov/pubmed/29783679 http://dx.doi.org/10.3390/molecules23051211

Ejemplares similares

Statistical Evaluation of HTS Assays for Enzymatic Hydrolysis of β-Keto Esters
por: Buß, O., et al.
Publicado: (2016)

Recent advances in the transesterification of β-keto esters
por: Hennessy, M. C., et al.
Publicado: (2021)

Copper-catalyzed cascade reactions of α,β-unsaturated esters with keto esters
por: Li, Zhengning, et al.
Publicado: (2015)

Stereoselective Bioreduction of α-diazo-β-keto Esters
por: González-Granda, Sergio, et al.
Publicado: (2020)

Growth optimization and identification of an ω-transaminase by a novel native PAGE activity staining method in a Bacillus sp. strain BaH isolated from Iranian soil
por: Gord Noshahri, Najme, et al.
Publicado: (2021)

Development of β -keto ester and malonate chemistry: Palladium-catalyzed new reactions of their allylic esters
por: Tsuji, Jiro
Publicado: (2004)

Quorum Sensing Inhibition and Structure–Activity Relationships of β-Keto Esters
por: Forschner-Dancause, Stephanie, et al.
Publicado: (2016)

Asymmetric Preparation of α-Quaternary Fluorinated β-keto Esters. Review
por: Granados, Albert, et al.
Publicado: (2020)

Transaminases for the synthesis of enantiopure beta-amino acids
por: Rudat, Jens, et al.
Publicado: (2012)

Ammonium Salt‐Catalyzed Ring‐Opening of Aryl‐Aziridines with β‐Keto Esters
por: Haider, Victoria, et al.
Publicado: (2020)

Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes
por: Begum, Zubeda, et al.
Publicado: (2020)

Dynamic Kinetic Asymmetric Cross-Benzoin Additions of β-Stereogenic α-Keto Esters
por: Goodman, C. Guy, et al.
Publicado: (2014)

Manganese(II) Oxidizing Bacteria as Whole-Cell Catalyst for β-Keto Ester Oxidation
por: Guo, Juan, et al.
Publicado: (2020)

Synthesis of Functionalized δ‐Hydroxy‐β‐keto Esters and Evaluation of Their Anti‐inflammatory Properties
por: Grosse, Michel, et al.
Publicado: (2022)

Quantum Chemical Study of Dual-Substrate Recognition in ω-Transaminase
por: Manta, Bianca, et al.
Publicado: (2017)

Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters
por: Yan, Lin, et al.
Publicado: (2013)

Asymmetric α-amination of β-keto esters using a guanidine–bisurea bifunctional organocatalyst
por: Odagi, Minami, et al.
Publicado: (2016)

Stereodivergent dehydrative allylation of β-keto esters using a Ru/Pd synergistic catalyst
por: Le, Thien Phuc, et al.
Publicado: (2022)

Selective synthesis of α-organylthio esters and α-organylthio ketones from β-keto esters and sodium S-organyl sulfurothioates under basic conditions
por: Kazmierczak, Jean C, et al.
Publicado: (2021)

Lipase-Mediated Mechanoenzymatic Synthesis of Sugar Esters in Dissolved Unconventional and Neat Reaction Systems
por: Hollenbach, Rebecca, et al.
Publicado: (2022)

Enhancing a Sphaerobacter thermophilus ω-transaminase for kinetic resolution of β- and γ-amino acids
por: Wegner, Uwe, et al.
Publicado: (2023)

Grubbs Cross-Metathesis Pathway for a Scalable Synthesis of γ-Keto-α,β-unsaturated Esters
por: Nair, Reji N., et al.
Publicado: (2014)

Asymmetric Electrophilic Difluoromethylthiolation of Indanone-Based β-Keto Esters Using Difluoromethanesulfonyl Hypervalent Iodonium Ylides
por: Gondo, Satoshi, et al.
Publicado: (2019)

Stereoselective α-Chlorination of β-Keto Esters in the Presence of Hybrid Amide-Based Cinchona Alkaloids as Catalysts
por: Majdecki, Maciej, et al.
Publicado: (2020)

N-Cinnamoyl-l-phenylalanine methyl ester
por: Bornaghi, Laurent F., et al.
Publicado: (2007)

Asymmetric reduction of ketones and β-keto esters by (S)-1-phenylethanol dehydrogenase from denitrifying bacterium Aromatoleum aromaticum
por: Dudzik, A., et al.
Publicado: (2014)

H-Bond Mediated Phase-Transfer Catalysis: Enantioselective Generating of Quaternary Stereogenic Centers in β-Keto Esters
por: Niedbała, Patryk, et al.
Publicado: (2022)

Total Synthesis of Marine Alkaloids Motuporamines A and B via Ring Expansion of Cyclic β-Keto Esters
por: Song, Zi-Jie, et al.
Publicado: (2020)

Organocatalytic Asymmetric Peroxidation of γ,δ-Unsaturated β-Keto Esters—A Novel Route to Chiral Cycloperoxides
por: Hennessy, Mary C., et al.
Publicado: (2023)

Highly efficient and recyclable chiral phosphine-functionalized polyether ionic liquids for asymmetric hydrogenation of β-keto esters
por: Wang, Fan, et al.
Publicado: (2023)

A convenient enantioselective decarboxylative aldol reaction to access chiral α-hydroxy esters using β-keto acids
por: Duan, Zhiqiang, et al.
Publicado: (2014)

Highly Functionalized 1,2–Diamino Compounds through Reductive Amination of Amino Acid-Derived β–Keto Esters
por: Pérez-Faginas, Paula, et al.
Publicado: (2013)

4-Dimethylaminopyridine-Catalyzed Metal-Free Aerobic Oxidation of Aryl α-Halo Esters to Aryl α-Keto Esters
por: Jung, Yeonghun, et al.
Publicado: (2020)

N-Heterocyclic carbene-catalyzed direct cross-aza-benzoin reaction: Efficient synthesis of α-amino-β-keto esters
por: Uno, Takuya, et al.
Publicado: (2012)

Design of β-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation, and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity
por: Martínez-Cifuentes, Maximiliano, et al.
Publicado: (2023)

Enantiomer discrimination in β-phenylalanine degradation by a newly isolated Paraburkholderia strain BS115 and type strain PsJN
por: Buß, Oliver, et al.
Publicado: (2018)

Robust ω-Transaminases by Computational Stabilization of the Subunit Interface
por: Meng, Qinglong, et al.
Publicado: (2020)

Development of Guanidine-Bisurea Bifunctional Organocatalysts with a Chiral Pyrrolidine Moiety and Application to α-Hydroxylation of Tetralone-Derived β-Keto Esters
por: Odagi, Minami, et al.
Publicado: (2015)

Asymmetric α‐Chlorination of β‐Keto Esters Using Hypervalent Iodine‐Based Cl‐Transfer Reagents in Combination with Cinchona Alkaloid Catalysts
por: Stockhammer, Lotte, et al.
Publicado: (2020)

Base-iodine-promoted metal-catalyst-free reactions of [60]fullerene with β-keto esters for the selective formation of [60]fullerene derivatives
por: Yang, Han-Lin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fvo8uijef47ll0ci34aiu8evpk