Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis

Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, an...

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Detalles Bibliográficos
Autores principales: Guo, Da-Le, Li, Xiao-Hua, Feng, Dan, Jin, Meng-Ying, Cao, Yu-Mei, Cao, Zhi-Xing, Gu, Yu-Cheng, Geng, Zhao, Deng, Fang, Deng, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100219/
https://www.ncbi.nlm.nih.gov/pubmed/30011828
http://dx.doi.org/10.3390/molecules23071709
Descripción
Sumario:Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC(50) values of 23.95 µM and 32.70 µM, respectively.

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