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Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis
Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, an...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100219/ https://www.ncbi.nlm.nih.gov/pubmed/30011828 http://dx.doi.org/10.3390/molecules23071709 |
| _version_ | 1783348826150535168 |
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| author | Guo, Da-Le Li, Xiao-Hua Feng, Dan Jin, Meng-Ying Cao, Yu-Mei Cao, Zhi-Xing Gu, Yu-Cheng Geng, Zhao Deng, Fang Deng, Yun |
| author_facet | Guo, Da-Le Li, Xiao-Hua Feng, Dan Jin, Meng-Ying Cao, Yu-Mei Cao, Zhi-Xing Gu, Yu-Cheng Geng, Zhao Deng, Fang Deng, Yun |
| author_sort | Guo, Da-Le |
| collection | PubMed |
| description | Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC(50) values of 23.95 µM and 32.70 µM, respectively. |
| format | Online Article Text |
| id | pubmed-6100219 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61002192018-11-13 Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis Guo, Da-Le Li, Xiao-Hua Feng, Dan Jin, Meng-Ying Cao, Yu-Mei Cao, Zhi-Xing Gu, Yu-Cheng Geng, Zhao Deng, Fang Deng, Yun Molecules Article Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC(50) values of 23.95 µM and 32.70 µM, respectively. MDPI 2018-07-13 /pmc/articles/PMC6100219/ /pubmed/30011828 http://dx.doi.org/10.3390/molecules23071709 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Guo, Da-Le Li, Xiao-Hua Feng, Dan Jin, Meng-Ying Cao, Yu-Mei Cao, Zhi-Xing Gu, Yu-Cheng Geng, Zhao Deng, Fang Deng, Yun Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title | Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_full | Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_fullStr | Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_full_unstemmed | Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_short | Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_sort | novel polyketides produced by the endophytic fungus aspergillus fumigatus from cordyceps sinensis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100219/ https://www.ncbi.nlm.nih.gov/pubmed/30011828 http://dx.doi.org/10.3390/molecules23071709 |
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