Cargando…

Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition

Bergamottin (BGM) is a naturally occurring furanocoumarin and is known to inhibit the growth of tumor cells. However, there is no available evidence that BGM has an inhibitory effect on cancer metastasis, specifically on the epithelial-to-mesenchymal transition (EMT) process in the malignant cells....

Descripción completa

Detalles Bibliográficos
Autores principales:	Ko, Jeong-Hyeon, Nam, Dongwoo, Um, Jae-Young, Jung, Sang Hoon, Sethi, Gautam, Ahn, Kwang Seok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100248/ https://www.ncbi.nlm.nih.gov/pubmed/30004418 http://dx.doi.org/10.3390/molecules23071601

Ejemplares similares

A Novel Role of Bergamottin in Attenuating Cancer Associated Cachexia by Diverse Molecular Mechanisms
por: Jung, Young Yun, et al.
Publicado: (2021)

Pharmacological Utilization of Bergamottin, Derived from Grapefruits, in Cancer Prevention and Therapy
por: Ko, Jeong-Hyeon, et al.
Publicado: (2018)

Procaine Abrogates the Epithelial-Mesenchymal Transition Process through Modulating c-Met Phosphorylation in Hepatocellular Carcinoma
por: Yang, Min Hee, et al.
Publicado: (2022)

2,3,5,6-Tetramethylpyrazine Targets Epithelial-Mesenchymal Transition by Abrogating Manganese Superoxide Dismutase Expression and TGFβ-Driven Signaling Cascades in Colon Cancer Cells
por: Jung, Young Yun, et al.
Publicado: (2022)

Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade
por: Hwang, Sun Tae, et al.
Publicado: (2020)

Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2018)

Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model
por: Kim, Chulwon, et al.
Publicado: (2019)

Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade
por: Jung, Young Yun, et al.
Publicado: (2018)

Potential Application of Leelamine as a Novel Regulator of Chemokine-Induced Epithelial-to-Mesenchymal Transition in Breast Cancer Cells
por: Jung, Young Yun, et al.
Publicado: (2022)

Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
por: Kim, Chulwon, et al.
Publicado: (2015)

Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade
por: Yang, Min Hee, et al.
Publicado: (2019)

Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade
por: Lee, Jong Hyun, et al.
Publicado: (2019)

Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades
por: Lee, Hanwool, et al.
Publicado: (2017)

Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis
por: Shanmugam, Muthu K., et al.
Publicado: (2018)

Euphorbiasteroid Abrogates EGFR and Wnt/β-Catenin Signaling in Non-Small-Cell Lung Cancer Cells to Impart Anticancer Activity
por: Kim, Na Young, et al.
Publicado: (2022)

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2020)

Attenuation of STAT3 Signaling Cascade by Daidzin Can Enhance the Apoptotic Potential of Bortezomib against Multiple Myeloma
por: Yang, Min Hee, et al.
Publicado: (2019)

The Application of Embelin for Cancer Prevention and Therapy †
por: Ko, Jeong-Hyeon, et al.
Publicado: (2018)

Euphorbiasteroid Induces Apoptosis as Well as Autophagy through Modulating SHP-1/STAT3 Pathway in Hepatocellular Carcinoma Cells
por: Kim, Na Young, et al.
Publicado: (2023)

The Role of Resveratrol in Cancer Therapy
por: Ko, Jeong-Hyeon, et al.
Publicado: (2017)

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model
por: Siveen, Kodappully Sivaraman, et al.
Publicado: (2013)

2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway
por: Ko, Jeong-Hyeon, et al.
Publicado: (2017)

Synthesis of Spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity
por: Zsidó, Balázs Zoltán, et al.
Publicado: (2020)

Bergamottin and PAP-1 Induced ACE2 Degradation to Alleviate Infection of SARS-CoV-2
por: Li, Mengjia, et al.
Publicado: (2022)

Bergamottin Inhibits PRRSV Replication by Blocking Viral Non-Structural Proteins Expression and Viral RNA Synthesis
por: Zhu, Zhenbang, et al.
Publicado: (2023)

Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer
por: Lee, Jong Hyun, et al.
Publicado: (2016)

Fangchinoline diminishes STAT3 activation by stimulating oxidative stress and targeting SHP-1 protein in multiple myeloma model
por: Jung, Young Yun, et al.
Publicado: (2021)

Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB
por: An, Ning, et al.
Publicado: (2021)

Bergamottin, a bioactive component of bergamot, inhibits SARS-CoV-2 infection in golden Syrian hamsters
por: Zhou, Minmin, et al.
Publicado: (2022)

Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer
por: Ashrafizadeh, Milad, et al.
Publicado: (2020)

Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2019)

Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer
por: Liang, S-Q, et al.
Publicado: (2015)

Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis
por: Datta, Arpita, et al.
Publicado: (2021)

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
por: Siveen, Kodappully Sivaraman, et al.
Publicado: (2014)

Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma
por: Zhang, Jing, et al.
Publicado: (2019)

Leelamine Modulates STAT5 Pathway Causing Both Autophagy and Apoptosis in Chronic Myelogenous Leukemia Cells
por: Jung, Young Yun, et al.
Publicado: (2022)

Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model
por: Yang, Min Hee, et al.
Publicado: (2023)

Co-administration of fresh grape fruit juice (GFJ) and bergamottin prevented paracetamol induced hepatotoxicity after paracetamol overdose in rats
por: Baleni, Refuoe, et al.
Publicado: (2015)

Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis
por: Zhao, Zhongfang, et al.
Publicado: (2021)

Correction to: Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma
por: Zhang, Jing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g8dq3a8ffb3p3b85sbf9mepu3v