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Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects

The antibacterial effects against Staphylococcus epidermidis of five silver carboxylate complexes with anti-inflammatory ligands were studied in order to analyze and compare them in terms of stability (in solution and after exposure to UV light), and their antibacterial and morphological differences...

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Autores principales: Aldabaldetrecu, Maialen, Tamayo, Laura, Alarcon, Romina, Walter, Mariana, Salas-Huenuleo, Edison, Kogan, Marcelo J., Guerrero, Juan, Paez, Maritza, Azócar, Manuel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100285/
https://www.ncbi.nlm.nih.gov/pubmed/29973523
http://dx.doi.org/10.3390/molecules23071629
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author Aldabaldetrecu, Maialen
Tamayo, Laura
Alarcon, Romina
Walter, Mariana
Salas-Huenuleo, Edison
Kogan, Marcelo J.
Guerrero, Juan
Paez, Maritza
Azócar, Manuel I.
author_facet Aldabaldetrecu, Maialen
Tamayo, Laura
Alarcon, Romina
Walter, Mariana
Salas-Huenuleo, Edison
Kogan, Marcelo J.
Guerrero, Juan
Paez, Maritza
Azócar, Manuel I.
author_sort Aldabaldetrecu, Maialen
collection PubMed
description The antibacterial effects against Staphylococcus epidermidis of five silver carboxylate complexes with anti-inflammatory ligands were studied in order to analyze and compare them in terms of stability (in solution and after exposure to UV light), and their antibacterial and morphological differences. Four effects of the Ag-complexes were evidenced by transmission electronic microscopy (TEM) and scanning electronic microscopy (SEM): DNA condensation, membrane disruption, shedding of cytoplasmic material and silver compound microcrystal penetration of bacteria. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity. However, Ag-5Cl was the most stable against exposure UV light (365 nm). Cytotoxic effects were tested against two kinds of eukaryotic cells: murine fibroblast cells (T10 1/2) and human epithelial ovarian cancer cells (A2780). The main objective was to identify changes in their antibacterial properties associated with potential decomposition and the implications for clinical applications.
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spelling pubmed-61002852018-11-13 Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects Aldabaldetrecu, Maialen Tamayo, Laura Alarcon, Romina Walter, Mariana Salas-Huenuleo, Edison Kogan, Marcelo J. Guerrero, Juan Paez, Maritza Azócar, Manuel I. Molecules Article The antibacterial effects against Staphylococcus epidermidis of five silver carboxylate complexes with anti-inflammatory ligands were studied in order to analyze and compare them in terms of stability (in solution and after exposure to UV light), and their antibacterial and morphological differences. Four effects of the Ag-complexes were evidenced by transmission electronic microscopy (TEM) and scanning electronic microscopy (SEM): DNA condensation, membrane disruption, shedding of cytoplasmic material and silver compound microcrystal penetration of bacteria. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity. However, Ag-5Cl was the most stable against exposure UV light (365 nm). Cytotoxic effects were tested against two kinds of eukaryotic cells: murine fibroblast cells (T10 1/2) and human epithelial ovarian cancer cells (A2780). The main objective was to identify changes in their antibacterial properties associated with potential decomposition and the implications for clinical applications. MDPI 2018-07-04 /pmc/articles/PMC6100285/ /pubmed/29973523 http://dx.doi.org/10.3390/molecules23071629 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aldabaldetrecu, Maialen
Tamayo, Laura
Alarcon, Romina
Walter, Mariana
Salas-Huenuleo, Edison
Kogan, Marcelo J.
Guerrero, Juan
Paez, Maritza
Azócar, Manuel I.
Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects
title Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects
title_full Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects
title_fullStr Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects
title_full_unstemmed Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects
title_short Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects
title_sort stability of antibacterial silver carboxylate complexes against staphylococcus epidermidis and their cytotoxic effects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100285/
https://www.ncbi.nlm.nih.gov/pubmed/29973523
http://dx.doi.org/10.3390/molecules23071629
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