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Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis

Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for t...

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Autores principales: Li, Xing, Zhao, Li, Han, Juan-Juan, Zhang, Fei, Liu, Shuai, Zhu, Lin, Wang, Zhe-Zhi, Zhang, Guang-Xian, Zhang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100297/
https://www.ncbi.nlm.nih.gov/pubmed/30150982
http://dx.doi.org/10.3389/fimmu.2018.01807
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author Li, Xing
Zhao, Li
Han, Juan-Juan
Zhang, Fei
Liu, Shuai
Zhu, Lin
Wang, Zhe-Zhi
Zhang, Guang-Xian
Zhang, Yuan
author_facet Li, Xing
Zhao, Li
Han, Juan-Juan
Zhang, Fei
Liu, Shuai
Zhu, Lin
Wang, Zhe-Zhi
Zhang, Guang-Xian
Zhang, Yuan
author_sort Li, Xing
collection PubMed
description Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for the treatment of multiple autoimmune diseases (1). In this study, we investigated the therapeutic effects and molecule mechanism of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment significantly alleviated clinical development in the myelin oligodendrocyte glycoprotein (MOG(35–55)) peptide-induced EAE model, markedly decreased inflammatory cell infiltration into the central nervous system and reduced demyelination. Further, carnosol inhibited Th17 cell differentiation and signal transducer and activator of transcription 3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia. Taken together, our results show that carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as MS.
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spelling pubmed-61002972018-08-27 Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis Li, Xing Zhao, Li Han, Juan-Juan Zhang, Fei Liu, Shuai Zhu, Lin Wang, Zhe-Zhi Zhang, Guang-Xian Zhang, Yuan Front Immunol Immunology Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for the treatment of multiple autoimmune diseases (1). In this study, we investigated the therapeutic effects and molecule mechanism of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment significantly alleviated clinical development in the myelin oligodendrocyte glycoprotein (MOG(35–55)) peptide-induced EAE model, markedly decreased inflammatory cell infiltration into the central nervous system and reduced demyelination. Further, carnosol inhibited Th17 cell differentiation and signal transducer and activator of transcription 3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia. Taken together, our results show that carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as MS. Frontiers Media S.A. 2018-08-13 /pmc/articles/PMC6100297/ /pubmed/30150982 http://dx.doi.org/10.3389/fimmu.2018.01807 Text en Copyright © 2018 Li, Zhao, Han, Zhang, Liu, Zhu, Wang, Zhang and Zhang. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Xing
Zhao, Li
Han, Juan-Juan
Zhang, Fei
Liu, Shuai
Zhu, Lin
Wang, Zhe-Zhi
Zhang, Guang-Xian
Zhang, Yuan
Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
title Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
title_full Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
title_fullStr Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
title_full_unstemmed Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
title_short Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
title_sort carnosol modulates th17 cell differentiation and microglial switch in experimental autoimmune encephalomyelitis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100297/
https://www.ncbi.nlm.nih.gov/pubmed/30150982
http://dx.doi.org/10.3389/fimmu.2018.01807
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