Cargando…

Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies

Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties. Experimental and computational studies have reported on the therapeutic potential of polyamidoamine (PAMAM) dendrimers as solubility enhancers i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shadrack, Daniel M., Swai, Hulda S., Munissi, Joan J. E., Mubofu, Egid B., Nyandoro, Stephen S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100328/ https://www.ncbi.nlm.nih.gov/pubmed/29895742 http://dx.doi.org/10.3390/molecules23061419

Ejemplares similares

Synthesis of Polyamidoamine Dendrimer for Encapsulating Tetramethylscutellarein for Potential Bioactivity Enhancement
por: Shadrack, Daniel M., et al.
Publicado: (2015)

Preparation, Characterization and in Vivo Antimycobacterial Studies of Panchovillin-Chitosan Nanocomposites
por: Rwegasila, Edward, et al.
Publicado: (2016)

Solubility of aceclofenac in polyamidoamine dendrimer solutions
por: Patel, Jaydeep, et al.
Publicado: (2011)

Use of Polyamidoamine Dendrimers in Brain Diseases
por: Florendo, Maria, et al.
Publicado: (2018)

Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers
por: Jose, Jobin, et al.
Publicado: (2016)

A Mixed-Surface Polyamidoamine Dendrimer for In Vitro and In Vivo Delivery of Large Plasmids
por: Srinageshwar, Bhairavi, et al.
Publicado: (2020)

Polyamidoamine dendrimer impairs mitochondrial oxidation in brain tissue
por: Nyitrai, Gabriella, et al.
Publicado: (2013)

Optimization of Dendrimer Polyamidoamin Electrospun Nanofibers: Preparation and Properties
por: Zarei, Zahra, et al.
Publicado: (2022)

Polyamidoamine (PAMAM) Dendrimers Modified with Cathepsin-B Cleavable Oligopeptides for Enhanced Gene Delivery
por: Lee, Seulgi, et al.
Publicado: (2017)

Partial Surface Modification of Low Generation Polyamidoamine Dendrimers: Gaining Insight into their Potential for Improved Carboplatin Delivery
por: Nguyen, Dai Hai, et al.
Publicado: (2019)

Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo
por: Akhtar, Saghir, et al.
Publicado: (2015)

The Effect of Cationic Polyamidoamine Dendrimers on Physicochemical Characteristics of Hydrogels with Erythromycin
por: Wróblewska, Magdalena, et al.
Publicado: (2015)

Biotin-Containing Third Generation Glucoheptoamidated Polyamidoamine Dendrimer for 5-Aminolevulinic Acid Delivery System
por: Kaczorowska, Aleksandra, et al.
Publicado: (2021)

Second-Generation Polyamidoamine Dendrimer Conjugated with Oligopeptides Can Enhance Plasmid DNA Delivery In Vitro
por: Kim, Seongyeon, et al.
Publicado: (2023)

Ensemble-based screening of natural products and FDA-approved drugs identified potent inhibitors of SARS-CoV-2 that work with two distinct mechanisms
por: Shadrack, Daniel M., et al.
Publicado: (2021)

Evaluation of cationic polyamidoamine dendrimers’ dermal toxicity in the rat skin model
por: Winnicka, Katarzyna, et al.
Publicado: (2015)

Antiproliferative effect of double suicide gene delivery mediated by polyamidoamine dendrimers in human Tenon's capsule fibroblasts
por: Yang, Jin, et al.
Publicado: (2017)

Dual pH-sensitive and UCST-type thermosensitive dendrimers: phenylalanine-modified polyamidoamine dendrimers with carboxyl termini
por: Tamaki, Mamiko, et al.
Publicado: (2018)

Luteolin: a blocker of SARS-CoV-2 cell entry based on relaxed complex scheme, molecular dynamics simulation, and metadynamics
por: Shadrack, Daniel M., et al.
Publicado: (2021)

Retinal Delivery of the Protein Kinase C-β Inhibitor Ruboxistaurin Using Non-Invasive Nanoparticles of Polyamidoamine Dendrimers
por: Alshammari, Rehab A., et al.
Publicado: (2022)

Fluorinated polyamidoamine dendrimer-mediated miR-23b delivery for the treatment of experimental rheumatoid arthritis in rats
por: Han, Haobo, et al.
Publicado: (2023)

Potential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
por: Arima, Hidetoshi, et al.
Publicado: (2011)

Potential Biological Applications of Bio-Based Anacardic Acids and Their Derivatives
por: Hamad, Fatma B., et al.
Publicado: (2015)

Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA
por: Arima, Hidetoshi, et al.
Publicado: (2012)

Conjugation of Gentamicin to Polyamidoamine Dendrimers Improved Anti-bacterial Properties against Pseudomonas aeruginosa
por: Sheykhloo, Hamed, et al.
Publicado: (2021)

Conjugation of Short Oligopeptides to a Second-Generation Polyamidoamine Dendrimer Shows Antibacterial Activity
por: Kang, Namyoung, et al.
Publicado: (2023)

A Polyamidoamine Dendrimer-Based Electrochemical Immunosensor for Label-Free Determination of Epithelial Cell Adhesion Molecule- Expressing Cancer Cells
por: Xu, Jianguo, et al.
Publicado: (2019)

Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and cytotoxicity
por: Shao, Naimin, et al.
Publicado: (2011)

Which Dendrimer to Attain the Desired Properties? Focus on Phosphorhydrazone Dendrimers†
por: Caminade, Anne-Marie, et al.
Publicado: (2018)

Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules
por: Choudhary, Sonam, et al.
Publicado: (2017)

Apoptin Gene Delivery by the Functionalized Polyamidoamine (PAMAM) Dendrimer Modified with Ornithine Induces Cell Death of HepG2 Cells
por: Bae, Yoonhee, et al.
Publicado: (2017)

Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer
por: Gao, Song, et al.
Publicado: (2015)

The cellular uptake mechanism, intracellular transportation, and exocytosis of polyamidoamine dendrimers in multidrug-resistant breast cancer cells
por: Zhang, Jie, et al.
Publicado: (2016)

Polyamidoamine Dendrimers Decorated Multifunctional Polydopamine Nanoparticles for Targeted Chemo- and Photothermal Therapy of Liver Cancer Model
por: Grześkowiak, Bartosz F., et al.
Publicado: (2021)

Facile Synthesis of Cross-linked Hyperbranched Polyamidoamines Dendrimers for Efficient Hg(Ⅱ) Removal From Water
por: Geng, Xue, et al.
Publicado: (2021)

Effects of the surface charge of polyamidoamine dendrimers on cellular exocytosis and the exocytosis mechanism in multidrug-resistant breast cancer cells
por: Zhang, Jie, et al.
Publicado: (2021)

Surface Heparinization of a Magnesium-Based Alloy: A Comparison Study of Aminopropyltriethoxysilane (APTES) and Polyamidoamine (PAMAM) Dendrimers
por: Ebrahimi, Masoumeh, et al.
Publicado: (2022)

Development of bismuth sulfide nanorods and polyamidoamine dendrimer on reduced graphene oxide as electrode nanomaterials for electrochemical determination of salbutamol
por: Padash, Mahshid, et al.
Publicado: (2023)

Polyamidoamine Dendron-Bearing Lipids as Drug-Delivery Excipients
por: Sarigul, Ender, et al.
Publicado: (2022)

Carbon nanotube filled with magnetic iron oxide and modified with polyamidoamine dendrimers for immobilizing lipase toward application in biodiesel production
por: Fan, Yanli, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_62mrqihrrnjq7ltvqk5oeapabs