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Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides

An efficient and practical approach towards bifunctional phosphorus phenols has been developed through a reaction of diphenylphosphine oxide and the o-quinone methides in situ generated from 2-tosylalkyl phenols under basic conditions. This protocol features simple experimental procedures under mild...

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Detalles Bibliográficos
Autores principales: Chen, Zhangpei, Shi, Qinglong, Wang, Gongshu, Chen, Siwen, Hu, Jianshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100389/
https://www.ncbi.nlm.nih.gov/pubmed/29882878
http://dx.doi.org/10.3390/molecules23061240
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author Chen, Zhangpei
Shi, Qinglong
Wang, Gongshu
Chen, Siwen
Hu, Jianshe
author_facet Chen, Zhangpei
Shi, Qinglong
Wang, Gongshu
Chen, Siwen
Hu, Jianshe
author_sort Chen, Zhangpei
collection PubMed
description An efficient and practical approach towards bifunctional phosphorus phenols has been developed through a reaction of diphenylphosphine oxide and the o-quinone methides in situ generated from 2-tosylalkyl phenols under basic conditions. This protocol features simple experimental procedures under mild conditions and is easily scaled up. With this method, a variety of diarylmethyl phosphine oxides can be produced with up to 92% yield.
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spelling pubmed-61003892018-11-13 Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides Chen, Zhangpei Shi, Qinglong Wang, Gongshu Chen, Siwen Hu, Jianshe Molecules Brief Report An efficient and practical approach towards bifunctional phosphorus phenols has been developed through a reaction of diphenylphosphine oxide and the o-quinone methides in situ generated from 2-tosylalkyl phenols under basic conditions. This protocol features simple experimental procedures under mild conditions and is easily scaled up. With this method, a variety of diarylmethyl phosphine oxides can be produced with up to 92% yield. MDPI 2018-05-23 /pmc/articles/PMC6100389/ /pubmed/29882878 http://dx.doi.org/10.3390/molecules23061240 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Chen, Zhangpei
Shi, Qinglong
Wang, Gongshu
Chen, Siwen
Hu, Jianshe
Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides
title Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides
title_full Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides
title_fullStr Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides
title_full_unstemmed Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides
title_short Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides
title_sort straightforward synthesis of bifunctional phosphorus phenols via phosphination of in situ generated o-quinone methides
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100389/
https://www.ncbi.nlm.nih.gov/pubmed/29882878
http://dx.doi.org/10.3390/molecules23061240
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