Four New Lignans from Kadsura Interior and Their Bioactivity

A phytochemical investigation of the stems of Kadsura interior has led to an isolation of four new lignans, named kadsutherin E–H (1–4), together with two known lignans (5–6). The structures of the four new compounds were established on the basis of comprehensive spectroscopic analyses. Compounds 1–...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jiu-Shi, Zhang, Jin, Qi, Yao-Dong, Jia, Xiao-Guang, Zhang, Ben-Gang, Liu, Hai-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100398/
https://www.ncbi.nlm.nih.gov/pubmed/29861462
http://dx.doi.org/10.3390/molecules23061279
Descripción
Sumario:A phytochemical investigation of the stems of Kadsura interior has led to an isolation of four new lignans, named kadsutherin E–H (1–4), together with two known lignans (5–6). The structures of the four new compounds were established on the basis of comprehensive spectroscopic analyses. Compounds 1–6 exhibited inhibition against adenosine diphosphate (ADP) induced platelet aggregation. Among the isolated compounds, kadsutherin F (2) showed the strongest anti-platelet aggregation activity with an inhibition of 49.47%.

Ejemplares similares