Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities

Seven pyrrole alkaloids, three of which are novel (phlebopines A–C (1–3)), were isolated from the fruiting bodies of the edible mushroom Phlebopus portentosus. Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective proper...

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Detalles Bibliográficos
Autores principales: Sun, Zhaocui, Hu, Meigeng, Sun, Zhonghao, Zhu, Nailiang, Yang, Junshan, Ma, Guoxu, Xu, Xudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100406/
https://www.ncbi.nlm.nih.gov/pubmed/29772776
http://dx.doi.org/10.3390/molecules23051198
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author Sun, Zhaocui
Hu, Meigeng
Sun, Zhonghao
Zhu, Nailiang
Yang, Junshan
Ma, Guoxu
Xu, Xudong
author_facet Sun, Zhaocui
Hu, Meigeng
Sun, Zhonghao
Zhu, Nailiang
Yang, Junshan
Ma, Guoxu
Xu, Xudong
author_sort Sun, Zhaocui
collection PubMed
description Seven pyrrole alkaloids, three of which are novel (phlebopines A–C (1–3)), were isolated from the fruiting bodies of the edible mushroom Phlebopus portentosus. Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective properties and acetylcholine esterase (AChE) inhibition activities. Compound 7 displayed remarkable neuroprotective effects against hydrogen peroxide (H(2)O(2))-induced neuronal-cell damage in human neuroblastoma SH-SY5Y cells.
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spelling pubmed-61004062018-11-13 Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities Sun, Zhaocui Hu, Meigeng Sun, Zhonghao Zhu, Nailiang Yang, Junshan Ma, Guoxu Xu, Xudong Molecules Article Seven pyrrole alkaloids, three of which are novel (phlebopines A–C (1–3)), were isolated from the fruiting bodies of the edible mushroom Phlebopus portentosus. Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective properties and acetylcholine esterase (AChE) inhibition activities. Compound 7 displayed remarkable neuroprotective effects against hydrogen peroxide (H(2)O(2))-induced neuronal-cell damage in human neuroblastoma SH-SY5Y cells. MDPI 2018-05-17 /pmc/articles/PMC6100406/ /pubmed/29772776 http://dx.doi.org/10.3390/molecules23051198 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Zhaocui
Hu, Meigeng
Sun, Zhonghao
Zhu, Nailiang
Yang, Junshan
Ma, Guoxu
Xu, Xudong
Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities
title Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities
title_full Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities
title_fullStr Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities
title_full_unstemmed Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities
title_short Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities
title_sort pyrrole alkaloids from the edible mushroom phlebopus portentosus with their bioactive activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100406/
https://www.ncbi.nlm.nih.gov/pubmed/29772776
http://dx.doi.org/10.3390/molecules23051198
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