Cargando…
Targeting Transcription Factors for Cancer Treatment
Transcription factors are involved in a large number of human diseases such as cancers for which they account for about 20% of all oncogenes identified so far. For long time, with the exception of ligand-inducible nuclear receptors, transcription factors were considered as “undruggable” targets. Adv...
Autores principales: | Lambert, Mélanie, Jambon, Samy, Depauw, Sabine, David-Cordonnier, Marie-Hélène |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100431/ https://www.ncbi.nlm.nih.gov/pubmed/29921764 http://dx.doi.org/10.3390/molecules23061479 |
Ejemplares similares
-
Direct and Indirect Targeting of HOXA9 Transcription Factor in Acute Myeloid Leukemia
por: Lambert, Mélanie, et al.
Publicado: (2019) -
Protein Recognition in Drug-Induced DNA Alkylation: When the Moonlight Protein GAPDH Meets S23906-1/DNA Minor Groove Adducts
por: Savreux-Lenglet, Gaëlle, et al.
Publicado: (2015) -
Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication
por: Peixoto, Paul, et al.
Publicado: (2008) -
Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines
por: Nhili, Raja, et al.
Publicado: (2013) -
DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences
por: Lenglet, Gaëlle, et al.
Publicado: (2010)